ArticleThe journal of allergy and clinical immunology. Global2025
Disparities in health-related quality of life between patients with primary and secondary antibody deficiencies.
Article in The journal of allergy and clinical immunology. Global, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Bridging the Gap in Secondary Antibody Deficiencies: Current Evidence and Unmet Needs in Diagnosis and Management with Immunoglobulin Replacement.Clinical reviews in allergy & immunology · 2025Review
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5 authors.
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Abstract
Background: The impact and burden of antibody deficiencies, especially secondary antibody deficiency (SAD), among adult patients remain largely understudied. Specifically, the health-related quality of life (HRQoL) of patients with SAD, compared to patients with primary antibody deficiency (PAD) remains unknown. Objective: Our aim was to characterize and compare the HRQoL of adult patients diagnosed with PAD and SAD. Methods: Clinical and HRQoL questionnaire survey data (from the SF-36v2 Health Survey [SF-36v2]) of all adult patients diagnosed with PAD or SAD at Queen Mary Hospital (the only adult immunology center in Hong Kong) were analyzed and compared to data on the general population. Results: Among the 33 adult patients with antibody deficiency, 22 (66.7%) and 11 (33.3%) had PAD and SAD, respectively. Compared to the general population, patients with PAD scored significantly lower in 3 of 8 domains of the SF-36v2, namely, Role-Physical (81.0 vs 90.4 [ Conclusion: Patients with SAD reported significantly poorer HRQoL than patients with PAD. Despite significantly greater impairment in HRQoL, patients with SAD often remain underrepresented and may warrant particular attention in terms of physical support and resource allocation.
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