Evidence map›Paper›PMID 40656662›Full record

ArticleTherapeutic advances in hematology2025

Low-dose anti-thymocyte globulin combined with low-dose post-transplant cyclophosphamide: a novel approach to prevent graft-versus-host disease in haploidentical stem cell transplantation.

Neslihan Mandaci Ṣanli, Ali Ünal

Abstract read
In one paragraph

Article in Therapeutic advances in hematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Neslihan Mandaci ṢanliDepartment of Hematology and Bone Marrow Transplant Center, Erciyes University Faculty of Medicine, Talas Boulevard No: 82, Melikgazi District, Kayseri 38039, Türkiye.ORCID https://orcid.org/0000-0002-6298-9884
Ali ÜnalDepartment of Hematology and Bone Marrow Transplant Center, Erciyes University Faculty of Medicine, Kayseri, Türkiye.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: In haploidentical hematopoietic stem cell transplantation (haplo-HSCT), combining low-dose post-transplant cyclophosphamide (PTCy) with low-dose anti-thymocyte globulin (ATG) is increasingly recognized as a promising approach for graft-versus-host disease (GVHD) prevention. Methods: This study evaluated 33 patients undergoing haplo-HSCT for hematological disorders, divided into two groups: low-dose ATG/PTCy ( Results: The incidence of grades I-II acute GVHD (aGVHD) was 11.8% in the low-dose ATG/PTCy group compared to 31.3% in the PTCy-only group ( Conclusion: The combination of low-dose ATG and PTCy appears to significantly reduce moderate cGVHD and NRM in haplo-HSCT compared to PTCy alone. To the best of our knowledge, this is the first study directly comparing these two regimens.

Indexed as

anti-thymocyte globulingraft-versus-host diseasehaploidenticallow-dosepost-transplant cyclophosphamide

Identifiers

PMID40656662
PMCPMC12246534

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.