ArticleBJR open2025
Radiological phenotypes in pulmonary sarcoidosis: a reliability study of newly defined high-resolution computer tomography phenotypes.
Article in BJR open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Evaluation of Delphi high-resolution computed tomography phenotype classification for treatment-naïve patients with pulmonary sarcoidosis.Quantitative imaging in medicine and surgery · 2026Article
- Morphological computed tomography phenotypes in pulmonary sarcoidosis at diagnosis: splitting and lumping based on predictors of clinical progression.ERJ open research · 2026Article
- Outdated Frameworks, Missed Opportunities: A Call for Establishing Classification Criteria for Patients with Sarcoidosis.Rheumatology and therapy · 2026Review
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: An accurate morphological classification of distinct pulmonary phenotypes in sarcoidosis is lacking. Recently, a multinational Delphi study was conducted to reach a consensus on recognizable high-resolution computer tomography (HRCT) phenotypes in pulmonary sarcoidosis as a basis for a more distinctive classification. The reliability of these phenotypes has not yet been evaluated. Methods: HRCT scans of adult sarcoidosis patients from the pulmonology department of a single sarcoidosis referral center were scored by three blinded independent readers. Seven phenotypes were distinguished as described in the Delphi study. They were divided into two subgroups: "non-fibrotic" and "likely-to-be fibrotic". Intra- and inter-reader reliability for scoring the predominant phenotype and the subgroup was assessed using weighted Kappa (K Results: Forty-five patients (mean age, 47 years ± 12, 28 men) were included. For the scoring of the predominant phenotype, inter-reader reliability between all readers was substantial with an overall Fleiss' kappa of 0.69 (CI 0.622-0.765, Conclusions: The inter- and intra-reader reliability of the newly proposed HRCT phenotypes obtained from the Delphi study is very acceptable. Advances in knowledge: This study is the first to assess the reliability of these HRCT phenotypes and supports the use of them for classification purposes in future clinical and pathogenetic studies.
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