Evidence map›Paper›PMID 40656469›Full record

ArticleSurgical neurology international2025

Increased levels of tumor necrosis factor-alpha in rat with traumatic brain injury after NeuroAid (MLC 901) administration.

Rohadi, Bambang Priyanto, Andi Asadul Islam, Mochammad Hatta, Agussalim Bukhari, Rozikin, I Wayan Gede Artawan Eka Putra, Lalu Muhammad Abdurrosid, Krisna Tsaniadi Prihastomo

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In one paragraph

Article in Surgical neurology international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

RohadiDepartment of Neurosurgery, Medical Faculty of Mataram University, West Nusa Tenggara General Hospital, Mataram, Indonesia.
Bambang PriyantoDepartment of Neurosurgery, Medical Faculty of Mataram University, Mataram City, West Nusa Tenggara, Indonesia.
Andi Asadul IslamDepartment of Neurosurgery, Universitas Hasanuddin, Makassar, Sulawesi Selatan, Indonesia.
Mochammad HattaDepartment of Medical Research, Faculty of Medical, Hasanuddin University, Makassar, Sulawesi Selatan, Indonesia.
Agussalim BukhariDepartment of Medical Research, Faculty of Medical, Hasanuddin University, Makassar, Sulawesi Selatan, Indonesia.
RozikinResearch Unit, Medical Faculty of Mataram University, Mataram, West Nusa Tenggara, Indonesia.
I Wayan Gede Artawan Eka PutraDepartment of Public Health and Preventive Medicine, Medical Faculty of Udayana University, Denpasar, Bali, Indonesia.
Lalu Muhammad AbdurrosidDepartment of Medical Research, Medical Faculty, Mataram University, Mataram, West Nusa Tenggara, Indonesia.
Krisna Tsaniadi PrihastomoDepartment of Neurosurgery, Faculty of Medicine, Diponegoro University, Semarang, Central Java, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Tumor necrosis factor-alpha (TNF-α) is an inflammatory cytokine produced by macrophages in acute inflammatory processes and plays roles in cell signaling that cause necrosis and apoptosis. This study aimed to show whether there was an effect of Neuroaid (MLC 901) on TNF-α levels in rats with traumatic brain injury (TBI) measured using the Enzyme-linked immunosorbent assay in the peripheral blood. Methods: A total of 10 Sprague-Dawley rats were divided into two groups, one group was given MLC 901 ( Results: At 30 min after brain injury, the TNF-α level in the MLC 901 group was higher (3564.8) than the 0.9% NaCl group (3453.6), but it was not statistically significant ( Conclusion: MLC 901 increases TNF-α levels in rats with TBI, with a significant rise observed at 6 weeks, suggesting a sustained inflammatory response.

Indexed as

MLC 901Traumatic brain injuryTumor necrosis factor-alpha

Identifiers

PMID40656469
PMCPMC12255181

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.