An extremely rare case of epithelioid hemangioendothelioma presumed metastasis to the pineal body.

Kyota Miyauchi, Akihiro Inoue, Teruyuki Ono, Satoshi Suehiro, Hideaki Watanabe, Riko Kitazawa, Takeharu Kunieda

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Article in Surgical neurology international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Kyota MiyauchiDepartment of Neurosurgery, Ehime University School of Medicine, Toon, Japan.

Akihiro InoueDepartment of Neurosurgery, Ehime University School of Medicine, Toon, Japan.

Teruyuki OnoDivision of Diagnostic Pathology, Ehime University Hospital, Toon, Japan.

Satoshi SuehiroDepartment of Neurosurgery, Ehime University School of Medicine, Toon, Japan.

Hideaki WatanabeDepartment of Neurosurgery, Ehime University School of Medicine, Toon, Japan.

Riko KitazawaDivision of Diagnostic Pathology, Ehime University Hospital, Toon, Japan.

Takeharu KuniedaDepartment of Neurosurgery, Ehime University School of Medicine, Toon, Japan.

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6 · The paper itself

Abstract

Background: Epithelioid hemangioendothelioma (EHE) is a rare malignant endothelial tumor of blood and lymph vessels composed of epithelioid cells within a distinctive myxohyaline stroma. Its predilection sites are soft tissues, bone, lung, and liver, and intracranial metastases are extremely rare. We describe a case of EHE in an elderly patient with pineal body metastasis. Case Description: An 84-year-old man presented to our hospital with disturbance of consciousness. Neuroimaging showed hydrocephalus and pineal tumor with hemorrhage on computed tomography and gadolinium enhancement on T1-weighted magnetic resonance imaging. Cerebral angiography showed no obvious tumor staining. Conclusion: We present an extremely rare case of EHE presumed metastasis presenting as an isolated pineal region tumor. If a tumor with hemorrhage is found in the pineal body in an elderly patient, EHE should be considered in the differential diagnosis, even if it is a single tumor lesion.

Indexed as

Endothelial tumors of blood and lymph vesselsEpithelioid hemangioendotheliomaPineal body metastasisPositron emission tomographyWW domain containing transcription regulator 1-calmodulin-binding transcription activator 1 fusion gene

Identifiers

PMID40656461

DOI10.25259/SNI_330_2025

PMCPMC12255170

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