ArticleCureus2025
A Case Report on Hiccups Improvement With Gabapentin.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hiccups, or Singultus, are a common condition among individuals. Several medications are under research for hiccup management, including Gabapentin, an analog of the neurotransmitter γ-aminobutyric acid (GABA), which has shown effective outcomes in patients with persistent hiccups, highlighting the need for larger clinical studies to evaluate their efficacy and safety. Despite that, Gabapentin works on the α-2-δ subunit of calcium channels, mediating its effect. Like many hiccup treatments, the exact mechanism through which Gabapentin alleviates hiccups is not fully understood. This case reports an 87-year-old male with a 40-year history of chronic hiccups, unresponsive to traditional psychiatric treatments, including chlorpromazine and haloperidol. The patient began escitalopram 20 mg daily for low mood and later added gabapentin 300 mg three times a day, which significantly improved his hiccups to under 15 minutes daily without any side effects. This case highlights the efficacy and safety of Gabapentin as an effective and well-tolerated treatment for persistent hiccups of unknown cause.
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