Evidence map›Paper›PMID 40656331›Full record

ArticleCureus2025

Metastatic Hepatocellular Carcinoma Presenting as a Large Abdominal Mass and Secondary Varicocele in a Hepatitis B Patient: A Case Report.

Mmahaletchumy Manoharan, Muhammad Hamza Shahid, Daniyal Abbasi, Lohana Pooja, Abdul Haseeb Hasan

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mmahaletchumy ManoharanGeneral Surgery, University of North Sumatra, Medan, IDN.
Muhammad Hamza ShahidInternal Medicine, Akhtar Saeed Medical and Dental College, Lahore, PAK.
Daniyal AbbasiInternal Medicine, Akbar Niazi Teaching Hospital, Islamabad, PAK.
Lohana PoojaInternal Medicine, Liaquat University of Medical and Health Sciences, Jamshoro, PAK.
Abdul Haseeb HasanInternal Medicine, Mayo Hospital, Lahore, PAK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a rare and aggressive presentation of hepatocellular carcinoma in a 50-year-old man with a brief history of hepatitis B infection. The patient presented with a rapidly enlarging epigastric mass, recurrent hematemesis, and a newly developed left-sided varicocele. Imaging revealed a large exophytic hepatic mass with evidence of vascular displacement and intrahepatic metastases. Histopathological examination confirmed a diagnosis of poorly differentiated hepatocellular carcinoma. A multidisciplinary tumor board recommended palliative surgical debulking followed by systemic therapy to address tumor burden and improve quality of life. This case highlights the diagnostic and management challenges associated with atypical presentations of hepatocellular carcinoma in patients with minimal liver disease history.

Indexed as

abdominal massatypical presentationcase reportexophytic liver tumorgastrointestinal bleedinghepatitis bhepatocellular carcinomavaricocele

Identifiers

PMID40656331
PMCPMC12256098

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.