Evidence map›Paper›PMID 40656273›Full record

ArticleCureus2025

Reversal of Type 2 Diabetes in a Patient With Hashimoto's Thyroiditis Through Combined Pharmacologic and Lifestyle Intervention.

Sherif I Ramoun, Sherif A Zaki, Amr M Issa, Ahmed K Attalla

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sherif I RamounInternal Medicine/Pediatrics, Alexandria University Main Hospitals, Alexandria, EGY.
Sherif A ZakiDermatology, Alexandria University, Alexandria, EGY.
Amr M IssaInternal Medicine, Faculty of Medicine, Alexandria University, Alexandria, EGY.
Ahmed K AttallaIntensive Care Unit, Alexandria University Main Hospitals, Alexandria, EGY.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Type 2 diabetes mellitus (T2DM) is typically considered a progressive condition, but recent evidence suggests potential reversibility through structured lifestyle intervention. We report the case of a 32-year-old Egyptian female with Hashimoto's thyroiditis and newly diagnosed T2DM, confirmed by elevated fasting blood glucose and HbA1c levels. The patient was managed with once-daily metformin, continued levothyroxine, a 500-calorie daily energy deficit, and progressive resistance training three times per week. After 12 months, fasting glucose and HbA1c values decreased below the diagnostic thresholds for diabetes, allowing metformin to be discontinued. Follow-up at one, three, and six months post-intervention confirmed sustained biochemical remission. This case highlights the potential for reversing diabetes in select patients through a combined pharmacological and lifestyle approach.

Indexed as

autoimmune hypothyroidismcalorie restrictionhashimoto’s thyroiditislifestyle interventionmetformin withdrawalresistance trainingtype 2 diabetes remission

Identifiers

PMID40656273
PMCPMC12254714

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.