ArticleCureus2025
Five Cases of Biliary Peritonitis Due to Bile Leakage From the Gallbladder During Postoperative Hospitalization After Cardiovascular Surgery.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Biliary peritonitis due to bile leakage from the gallbladder is considered a rare clinical entity. However, at our institution, we encountered five such cases between January 2018 and December 2024, all occurring during the postoperative course following cardiovascular surgery. This report presents clinical backgrounds, preoperative and intraoperative findings, and histopathological characteristics of these cases. We present five cases of biliary peritonitis due to bile leakage from the gallbladder. Four cases were acalculous cholecystitis, and three patients lacked abdominal symptoms. All cases developed during hospitalization after cardiovascular surgeries, including total arch replacement (two cases), ventricular septal rupture repair (one case), femoral-popliteal artery bypass (one case), and endovascular aortic repair (EVAR) (one case). Preoperative imaging showed gallbladder wall thinning and reduced contrast enhancement, while intraoperative findings revealed ischemic changes on the gallbladder serosa with bile leakage. Four patients underwent laparoscopic cholecystectomy, and one underwent open surgery. Histopathological examination revealed necrotic changes extending to the subserosal layer or involving the full thickness of the gallbladder wall at the site of bile leakage. This condition is reported to be difficult to diagnose due to minimal abdominal symptoms. In our series, all five cases developed during the postoperative course of cardiovascular surgery but were successfully diagnosed and treated early, resulting in the survival of all patients. Preoperative CT showed advanced atherosclerotic changes in the aorta, with stenosis and calcifications, particularly in the proximal cystic artery. The combination of cardiovascular risk and systemic stress after major surgery may have contributed to the onset of this condition. Recognizing this condition may lead to early diagnosis and appropriate treatment interventions. Although rare, biliary peritonitis due to bile leakage from the gallbladder can occur with notable frequency during the postoperative course of cardiovascular surgery. Understanding its characteristic imaging findings and clinical context is important for early diagnosis and appropriate management.
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