ArticleCureus2025
Antibiotic Susceptibility Report of Bacteria Isolated From Blood Cultures of Neutropenic Sepsis Patients Undergoing Chemotherapy.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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8 authors.
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Abstract
Background Febrile neutropenia often occurs as a serious complication in patients receiving chemotherapy. It is regarded as an oncologic emergency due to its high morbidity and mortality, necessitating the prompt initiation of empirical antibiotic therapy. While gram-negative bacteria have historically been the primary cause of bloodstream infections in febrile neutropenic patients, recent shifts in bacterial epidemiology and antimicrobial resistance patterns underscore the need for regular evaluation of local data to inform treatment strategies. Methods This retrospective cohort study was conducted in the Department of Hematology at Victoria Hospital, Kirkcaldy, from January to December 2024. It analyzed blood culture results, antibiotic use, chemotherapy regimens, patient characteristics, and microbial susceptibility patterns. A total of 63 patients with an absolute neutrophil count of less than 0.5 were selected through a simple convenience sampling method. Demographic data were collected from ward admission records using a standardized data collection sheet. Blood culture results were retrieved from the laboratory information management system and analyzed using IBM SPSS Statistics for Windows, Version 23.0 (Released 2015; IBM Corp., Armonk, NY, USA). Results Among the 63 patients, 20 (32%) had at least one positive blood culture, with a male-to-female ratio of 3:2. Gram-positive bacteria accounted for the majority of isolates (11; 55%), followed by gram-negative bacteria (eight; 40%), and mixed growth in one case (5%).
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