ArticleCureus2025
Aggressive Basal Cell Carcinoma With Rib Metastasis: An Uncommon Presentation of a Common Skin Cancer.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Basal cell carcinoma (BCC) is the most common skin cancer, generally characterized by slow growth and minimal risk of metastasis. However, in rare cases, particularly those left untreated for extended periods, BCC can become deeply invasive and even metastatic. We report the case of a 72-year-old woman with a long-neglected ulcerating facial tumor that was ultimately diagnosed as BCC with extensive local invasion and biopsy-proven metastasis to the left anterior fifth rib. Imaging revealed destruction of the maxilla, orbit, and palate. The patient was managed with a multimodal approach, including hedgehog pathway inhibition with vismodegib, immune checkpoint blockade with cemiplimab, palliative radiation therapy, and ultimately extensive surgical resection. The coordinated therapeutic response led to clinical improvement and disease stabilization. This case underscores the potential aggressiveness of neglected BCC and reinforces the value of early detection and comprehensive, multidisciplinary management in advanced presentations.
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