Evidence map›Paper›PMID 40656197›Full record

ArticleFrontiers in pediatrics2025

Congenital toxoplasmosis: an observational retrospective study in the Eastern Sicily.

Maria Teresa Garozzo, Rosaria Garozzo, Pasqua Betta, Salvatore Cilauro, Alessandro Saporito, Pietro D'Amico, Gabriella Tina, Angela Motta, Alfredo Pulvirenti, Salvatore Alaimo and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Maria Teresa GarozzoUnit of Pediatrics and Pediatric Emergency, Cannizzaro Hospital, Catania, Italy.
Rosaria GarozzoUnit of Pediatric Clinic, Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
Pasqua BettaUnit of Neonatal Intensive Care, University Hospital "Policlinico", University of Catania, Catania, Italy.
Salvatore CilauroUnit of Neonatal Intensive Care, University Hospital "Policlinico", University of Catania, Catania, Italy.
Alessandro SaporitoUnit of Neonatal Intensive Care, University Hospital "Policlinico", University of Catania, Catania, Italy.
Pietro D'AmicoUnit of Neonatal Intensive Care, Cannizzaro Hospital, Catania, Italy.
Gabriella TinaUnit of Neonatal Intensive Care, Garibaldi Hospital, Catania, Italy.
Angela MottaUnit of Neonatal Intensive Care, Garibaldi Hospital, Catania, Italy.
Alfredo PulvirentiBioinformatics Unit, Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
Salvatore AlaimoBioinformatics Unit, Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
Laura SciutoUnit of Pediatrics, Lentini Hospital, Lentini, Italy.
Basilio PecorinoUnit of Gynecology, Department of Medicine and Surgery, University Kore of Enna, Enna, Italy.
Manuela CeccarelliUnit of Infectious Diseases, Department of Medicine and Surgery, University Kore of Enna, Enna, Italy.
Guido ScaliaLaboratory Analysis Unit, Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.
Tiziana TimpanaroUnit of Pediatric Clinic, Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
Martino RuggieriUnit of Pediatric Clinic, Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
Agata Polizzi *Unit of Pediatric Clinic, Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
Andrea D Praticò *Unit of Pediatrics, Department of Medicine and Surgery, University Kore of Enna, Enna, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Objectives: This study aimed to evaluate the incidence of congenital toxoplasmosis (CT) in a cohort of newborns and assess their neurological, ophthalmological, and auditory sequelae. Additionally, we examined correlations between infection rates, gestational age at maternal seroconversion, prenatal treatment, and postnatal outcomes. Methods: We studied a cohort of 220 newborns evaluated for suspected CT between 2000 and 2021 across three hospitals in Catania, Italy. Prenatal screening identified 98.6% of maternal infections. Collected data included gestational history, neonatal clinical data, and follow-up assessments. Results: Mother-to-child transmission (MTCT) occurred in 19.2% (29/151) of cases with available follow-up data. MTCT rates increased significantly with gestational age at maternal seroconversion: 5% in the first trimester, 23% in the second, and 63% in the third ( Conclusions: Prenatal screening is effective in identifying newborns at risk for CT who require close monitoring and treatment. While our findings align with literature regarding MTCT rates, they differ regarding symptomatic case correlations. Further studies are warranted to better understand the factors influencing disease progression and long-term outcomes.

Indexed as

congenital toxoplasmosisgestational agemother-to-child transmissionneurological sequelaeprenatal screening

Identifiers

PMID40656197
PMCPMC12245800

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.