Plasma levels of NO-related pathway molecules to predict post-transcatheter aortic valve implantation major adverse cardiovascular events: a prospective, multicenter study.

Introduction: Aortic stenosis (AS) is associated with alterations in the concentrations of nitric oxide (NO)-related pathway molecules, including arginine, asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA). Aim: We aimed to determine the effect of transcatheter aortic valve implantation (TAVI) on the concentrations of arginine, ADMA, and SDMA and to evaluate their predictive value for post-TAVI outcomes. Material and methods: In total, 128 patients with AS referred for TAVI were enrolled in the study. Blood samples were collected 1 day before TAVI and at hospital discharge. Concentrations of arginine, ADMA, and SDMA were measured using ultra performance liquid chromatography coupled with mass spectrometry. Results: Plasma concentrations of arginine, ADMA, and SDMA did not change after TAVI, compared to baseline ( Conclusions: Plasma concentrations of arginine, ADMA, and SDMA were not affected by TAVI and did not predict post-TAVI MACE. ADMA and SDMA negatively correlated with AS severity, which might indicate alterations in the NO/L-arginine pathway in patients with AS.