Evidence map›Paper›PMID 40656118›Full record

ReviewNeuroscience applied2024

Knowledge gaps in psychedelic medicalisation: Preclinical and neuroimaging mechanisms.

Drummond E-Wen McCulloch, Juan Pablo Lopez, Christina Dalla, Eero Castrén, David Erritzoe, Vibe G Frokjaer, Johan Lundberg, Katrin H Preller, Patrick MacDonald Fisher, Gitte Moos Knudsen

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuroscience applied, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Drummond E-Wen McCullochNeurobiology Research Unit, Rigshospitalet, and University of Copenhagen, Copenhagen, Denmark.
Juan Pablo LopezDepartment of Neuroscience, Karolinska Institute, Solna, 171 77, Sweden.
Christina DallaDepartment of Pharmacology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Eero CastrénNeuroscience Center, HiLIFE, University of Helsinki, Helsinki, Finland.
David ErritzoeCentre for Psychedelic Research, Department of Brain Sciences, Imperial College London, London, UK.
Vibe G FrokjaerNeurobiology Research Unit, Rigshospitalet, and University of Copenhagen, Copenhagen, Denmark.
Johan LundbergCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Region Stockholm, Karolinska University Hospital, SE-171 76, Stockholm, Sweden.
Katrin H PrellerPharmaco-Neuroimaging and Cognitive-Emotional Processing, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric University Hospital, University of Zurich, Zurich, Switzerland.
Patrick MacDonald FisherNeurobiology Research Unit, Rigshospitalet, and University of Copenhagen, Copenhagen, Denmark.
Gitte Moos KnudsenNeurobiology Research Unit, Rigshospitalet, and University of Copenhagen, Copenhagen, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Classical psychedelic drugs, e.g., psilocybin and LSD, stimulate the serotonin 2A receptor (5-HT2AR) and have recently been intensely investigated for their clinical effects in various brain disorders. At the ECNP "New Frontiers meeting" in March 2023, scientific experts in psychedelics met to identify key knowledge gaps in the mechanism of action of psychedelics as investigated using preclinical models and clinical neuroimaging. Key themes included the development of appropriate behavioural models for measuring acute and persisting effects, dose optimisation, molecular mechanisms of action, sex differences, and the acute and persisting effects of psychedelics on neurotransmitter release and functional brain activity.

Identifiers

PMID40656118
PMCPMC12244124

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.