ArticleNeuroscience applied2024
Psychoneuroendocrine profiles of unmedicated men with major depressive disorder and associations to treatment effects and sexual side-effects.
Article in Neuroscience applied, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02869035 (Predicting Treatment Outcome in Major Depressive Disorder), which is not on this map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Predicting Treatment Outcome in Major Depressive Disorder
Who cites it
2 citing papers in PubMed.
- Sexual Dysfunction in Traumatic Brain Injury: A Narrative Review and Call for Multidisciplinary Framework.Life (Basel, Switzerland) · 2025Review
- Sex hormones and serotonin 4 receptor brain binding in men with and without major depressive disorder.Neuroscience applied · 2025Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sex hormones are potentially involved in major depressive disorder (MDD) as there are sex differences in risk for depression, symptomatology and treatment efficacy. Such hormonal contributions to MDD have mainly been studied in women and scarcely in men. We, therefore, investigate whether testosterone and estradiol levels in unmedicated men with MDD are associated with depressive symptom profiles, SSRI treatment response, and sexual side-effects. Pretreatment plasma testosterone and estradiol were available from 26 unmedicated men (age 18-49). The patients were treated with 10-20 mg escitalopram for 12 weeks. Depression severity was measured by Hamilton Depression Rating Scale 17 (HAMD17), and treatment response was the change in HAMD6 from baseline. Sexual side-effects were assessed with a standardized clinician-rated scale. Pretreatment testosterone was positively associated with depression severity ( Data from: Clinical study (NCT02869035).
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