Evidence map›Paper›PMID 40656066›Full record

ArticleNeuroscience applied2024

The effect of physical exercise with cognitive training on inflammation and Alzheimer's disease biomarkers of Mild Cognitive Impairment patients.

Georgios Katsipis, Eleni E Tzekaki, Eleni G Andreadou, Christos Mouzakidis, Eleni N Baldimtsi, Eleni M Karathanasi, Mary Hassandra, Evangelos Galanis, Antonis Hatzigeorgiadis, Marios Goudas and 10 more

Abstract read
In one paragraph

Article in Neuroscience applied, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Clinical Effectiveness of Treatments for Mild Cognitive Impairment in Adults: A Systematic Review.European journal of investigation in health, psychology and education · 2025
    Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Georgios KatsipisLaboratory of Biochemistry, Department of Chemistry, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece.
Eleni E TzekakiLaboratory of Biochemistry, Department of Chemistry, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece.
Eleni G AndreadouLaboratory of Biochemistry, Department of Chemistry, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece.
Christos MouzakidisGreek Association of Alzheimer's Disease and Related Disorders (GAADRD), 54643, Thessaloniki, Greece.
Eleni N BaldimtsiGreek Association of Alzheimer's Disease and Related Disorders (GAADRD), 54643, Thessaloniki, Greece.
Eleni M KarathanasiGreek Association of Alzheimer's Disease and Related Disorders (GAADRD), 54643, Thessaloniki, Greece.
Mary HassandraSchool of Physical Education, Sport Science and Dietetics, Department of Physical Education and Sport Science, University of Thessaly, Trikala, Greece.
Evangelos GalanisSchool of Physical Education, Sport Science and Dietetics, Department of Physical Education and Sport Science, University of Thessaly, Trikala, Greece.
Antonis HatzigeorgiadisSchool of Physical Education, Sport Science and Dietetics, Department of Physical Education and Sport Science, University of Thessaly, Trikala, Greece.
Marios GoudasSchool of Physical Education, Sport Science and Dietetics, Department of Physical Education and Sport Science, University of Thessaly, Trikala, Greece.
Paul ZikasORamaVR SA, Science and Technology Park of Crete, Heraklion, Crete, Greece.
Giannis EvangelouORamaVR SA, Science and Technology Park of Crete, Heraklion, Crete, Greece.
George PapagiannakisORamaVR SA, Science and Technology Park of Crete, Heraklion, Crete, Greece.
George BellisBiomechanical Solutions Engineering (BME), Karditsa, Greece.
Christos KokkotisSchool of Physical Education, Sport Science and Dietetics, Department of Physical Education and Sport Science, University of Thessaly, Trikala, Greece.
Themistoklis TsatalasSchool of Physical Education, Sport Science and Dietetics, Department of Physical Education and Sport Science, University of Thessaly, Trikala, Greece.
Giannis GiakasSchool of Physical Education, Sport Science and Dietetics, Department of Physical Education and Sport Science, University of Thessaly, Trikala, Greece.
Yannis TheodorakisSchool of Physical Education, Sport Science and Dietetics, Department of Physical Education and Sport Science, University of Thessaly, Trikala, Greece.
Magda TsolakiCenter for Interdisciplinary Research and Innovation, Laboratory of Neurodegenerative Diseases (LND), 57001, Thermi, Thessaloniki, Greece.
Anastasia A PantazakiLaboratory of Biochemistry, Department of Chemistry, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Physical exercise (PE) was proven crucial for cognitive health of both demented and cognitively intact individuals. Simultaneous cognitive training may augment PE beneficial effects in demented patients. However, it is still debatable how PE and/or cognitive training reflect on mild cognitive impairment (MCI) and pathological factors related to Alzheimer's disease, namely inflammatory cytokines interleukin (IL) 1 beta and 6, tumor necrosis factor alpha (TNF-α), amyloid beta (Αβ) peptides, total tau protein (t-tau) and tau phosphorylated at threonine 181 (p-tau181). In the current study, 74 MCI patients were allocated to three groups: non-intervention (Control), PE, and PE with cognitive training (Mixed). Blood serum was received at the Baseline and after the intervention (at 3 months). Levels of IL-1β, IL-6, TNF-α, Αβ

Indexed as

BiomarkersCognitive trainingMCINeuroinflammationPhysical exercisep-tau181/Αβ42

Identifiers

PMID40656066
PMCPMC12243983

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.