Evidence map›Paper›PMID 40656058›Full record

ArticleNeuroscience applied2024

Lithium treatment for affective disorders: Exploring the potential of salivary therapeutic monitoring.

Maja P Völker, Lea Sirignano, Helene Dukal, Alexander Schwesinger, Peter Findeisen, Fabian Schummer, Nils Hummel, Juliana Bresele, Michael Schneider, Joachim Behr and 17 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience applied, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Maja P VölkerDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Lea SirignanoDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Helene DukalDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Alexander SchwesingerDepartment of Psychiatry and Psychotherapy, RG Stress, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany.
Peter FindeisenMVZ Laboratory Limbach, Heidelberg, Germany.
Fabian SchummerDepartment of Psychiatry, Psychotherapy and Psychosomatics, University Hospital Ruppin-Brandenburg, Brandenburg Medical School Theodor Fontane, Faculty of Health Sciences Brandenburg, Neuruppin, Germany.
Nils HummelDepartment of Neurology, University Hospital Ruppin-Brandenburg, Brandenburg Medical School Theodor Fontane, Neuruppin, Germany.
Juliana BreseleDepartment of Psychiatry, Psychotherapy and Psychosomatics, University Hospital Ruppin-Brandenburg, Brandenburg Medical School Theodor Fontane, Faculty of Health Sciences Brandenburg, Neuruppin, Germany.
Michael SchneiderUniversity Clinic for Psychiatry and Psychotherapy, Brandenburg Medical School Theodor Fontane, Rüdersdorf, Germany.
Joachim BehrDepartment of Psychiatry, Psychotherapy and Psychosomatics, University Hospital Ruppin-Brandenburg, Brandenburg Medical School Theodor Fontane, Faculty of Health Sciences Brandenburg, Neuruppin, Germany.
Thomas StammDepartment of Psychology, Brandenburg Medical School Theodor Fontane, Faculty of Health Sciences Brandenburg, Neuruppin, Germany.
Oliver ZolkInstitute of Clinical Pharmacology, Brandenburg Medical School Theodor Fontane, Faculty of Health Sciences Brandenburg, Rüdersdorf, Germany.
Anne PietznerDepartment of Medicine B, University Hospital Ruppin-Brandenburg, Brandenburg Medical School Theodor Fontane, Neuruppin, Germany.
Michael HauptmannInstitute of Biostatistics and Registry Research, Brandenburg Medical School Theodor Fontane, Faculty of Health Sciences Brandenburg, Neuruppin, Germany.
Tino GraßhofCubeoffice GmbH & Co.KG, Magdeburg, Germany.
Michael HartlepTrace Analytics GmbH, Braunschweig, Germany.
Manfred DeckerKurt-Schwabe-Institut für Mess- und Sensortechnik e.V. Meinsberg, Kurt-Schwabe-Straße 4, D- 04736, Waldheim, Germany.
Anne MüllerKurt-Schwabe-Institut für Mess- und Sensortechnik e.V. Meinsberg, Kurt-Schwabe-Straße 4, D- 04736, Waldheim, Germany.
Frank GerlachKurt-Schwabe-Institut für Mess- und Sensortechnik e.V. Meinsberg, Kurt-Schwabe-Straße 4, D- 04736, Waldheim, Germany.
Winfried VonauKurt-Schwabe-Institut für Mess- und Sensortechnik e.V. Meinsberg, Kurt-Schwabe-Straße 4, D- 04736, Waldheim, Germany.
Stephanie H WittDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Douglas A GrangerInstitute for Interdisciplinary Salivary Bioscience Research, University of California Irvine, Irvine, CA, USA.
Georgia M ParkinInstitute for Interdisciplinary Salivary Bioscience Research, University of California Irvine, Irvine, CA, USA.
Elizabeth A ThomasInstitute for Interdisciplinary Salivary Bioscience Research, University of California Irvine, Irvine, CA, USA.
Maria GillesDepartment of Psychiatry and Psychotherapy, RG Stress, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany.
Marcella RietschelDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Pichit BuspavanichDepartment of Psychiatry, Psychotherapy and Psychosomatics, University Hospital Ruppin-Brandenburg, Brandenburg Medical School Theodor Fontane, Faculty of Health Sciences Brandenburg, Neuruppin, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lithium is one of the most effective medications for treatment-resistant depression and bipolar disorder. However, lithium has a narrow therapeutic window: overdosing can lead to life-threatening lithium intoxication while underdosing results in a lack of desired therapeutic effects. Therefore, lithium treatment requires close monitoring with regular laboratory assessments of blood serum concentrations. An alternative method for monitoring lithium at home would increase the safety and empowerment of patients. In our project, we are investigating the potential of saliva as a readily accessible medium. We are exploring a) the best method for collecting and processing saliva, b) methods to measure salivary lithium levels, and c) the correlation between blood serum and saliva concentrations of lithium, and influencing factors; with the aim to develop a Point-of-care home testing device.

Identifiers

PMID40656058
PMCPMC12244003

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.