ReviewNeuroscience applied2024
Role of histone deacetylases in neuroplasticity impairments and inflammation in major depression.
Review in Neuroscience applied, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Epigenetic Control of Stress-Induced Depression: Emerging Roles of HDAC3 and HDAC6.International journal of molecular sciences · 2026Review
- Epigenetic, neuroplasticity, and adrenergic targets associated with major depression in immune cells.Scientific reports · 2026Article
- Does the Microbiota-Gut-Brain Axis Mediate the Antidepressant Effects of Acupuncture? A Structured Review of Preclinical and Clinical Evidence.Neuropsychiatric disease and treatment · 2026Review
- From synapse to system: mechanistic pathways of neural signaling dysfunction in psychiatric disorders.Frontiers in cell and developmental biology · 2026Review
- Understanding the Comorbidities Among Psychiatric Disorders, Chronic Low Back Pain, and Spinal Degenerative Disease Using Observational and Genetically Informed Analyses.Biological psychiatry global open science · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This paper critically reviews the interesting and extensive knowledge regarding the role of some HDACs in major depression. MD is associated with neuroplasticity failure and inflammatory events, in which, several histone deacetylase (HDACs) enzymes play a key role. Specifically, increased expression of specific HDACs are linked to depressive-like behaviour, repress the expression of the brain derived neurotrophic factor (BDNF), and induce a pro-inflammatory response. Conversely, other HDACs exert an antidepressant action, promote dendritic growth and protect neurons or immune cells from inflammatory events. The right balance between both types is needed to respond correctly to the different physiological/pathological stimuli. However, aberrant expressions or activities of specific HDACs could be associated with MD. Further studies should identify the mechanism by which MD regulates specific HDAC subtypes both in post-mortem brain tissue and in peripheral immune cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.