Evidence map›Paper›PMID 40656032›Full record

ArticleIndian journal of psychiatry2025

Fixed dose combination dextromethorphan-bupropion: A hope for treatment resistant depression (TRD).

Ranjan Das, Rajarshi Chakravarty, Varaha V Gantait, Subir Bhattacharjee

Abstract read
In one paragraph

Article in Indian journal of psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ranjan DasDepartment of Psychiatry, IOP-COE, IPGMER, Kolkata, West Bengal, India.
Rajarshi ChakravartyDepartment of Psychiatry, Jhargram Govt. Medical College and Hospital, Vidyasagar Pally, Jhargram, West Bengal, India.
Varaha V GantaitDepartment of Psychiatry, IQ City Medical College, Durgapur, West Bengal, India.
Subir BhattacharjeeDepartment of Psychiatry, Deben Mahata Govt. Medical College and Hospital, Hatuara, Purulia, West Bengal, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Treatment resistant depression (TRD) has been identified as non-response to depression with adequate dose and trial of two antidepressant medications of different classes. Near about 30% depressive patients are TRD cases. Olanzapine-fluoxetine combination, rTMS, Intravenous ketamine and Electroconvulsive therapy have been till now studied in TRD. Dextromethorphan-bupropion is a newer antidepressant, which has been found to be effective, fast-acting, and well tolerated medicine for depression. Cases and conclusion: We used this novel antidepressant in three cases of TRD, alone and with combination, and it showed satisfactory response within 2 weeks.

Indexed as

Depressiondextromethorphan-bupropiontreatment resistant depression

Identifiers

PMID40656032
PMCPMC12250243

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.