Evidence map›Paper›PMID 40655991›Full record

ArticleData in brief2025

Proteomic profile data of rabbit stem cell secretome and stem cell/tenocyte secretome and gene expression data, scratch assay data and CAM assay data of tenocyte in vitro cultures treated with these two different secretomes.

Petra Wolint, Iris Miescher, Asma Mechakra, Patrick Jäger, Julia Rieber, Maurizio Calcagni, Pietro Giovanoli, Viola Vogel, Jess G Snedeker, Johanna Buschmann

Abstract read
In one paragraph

Article in Data in brief, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Petra WolintDivision of Surgical Research, University Hospital of Zurich, 8091 Zurich, Switzerland.
Iris MiescherDepartment of Plastic Surgery and Hand Surgery, University Hospital Zurich, 8091 Zurich, Switzerland.
Asma MechakraInstitute for Biomechanics, ETH Zurich, 8092 Zurich, Switzerland.
Patrick JägerInstitute for Biomechanics, ETH Zurich, 8092 Zurich, Switzerland.
Julia RieberDepartment of Plastic Surgery and Hand Surgery, University Hospital Zurich, 8091 Zurich, Switzerland.
Maurizio CalcagniDepartment of Plastic Surgery and Hand Surgery, University Hospital Zurich, 8091 Zurich, Switzerland.
Pietro GiovanoliDepartment of Plastic Surgery and Hand Surgery, University Hospital Zurich, 8091 Zurich, Switzerland.
Viola VogelLaboratory of Applied Mechanobiology, Department of Health Sciences and Technology, ETH Zurich, 8092 Zurich, Switzerland.
Jess G SnedekerInstitute for Biomechanics, ETH Zurich, 8092 Zurich, Switzerland.
Johanna BuschmannDivision of Surgical Research, University Hospital of Zurich, 8091 Zurich, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tendon rupture repairs exhibit two main problems. On the one hand side, they often lead to scar formation during healing, which has inferior mechanical properties and may lead to re-ruptures. On the other hand side, fibrotic adhesion formation to the surrounding tissue may occur, which hampers proper range of motion. Cell-free approaches to support tendon healing are getting increasing attention worldwide. We have therefore obtained two different cell secretomes from New Zealand White rabbit adipose tissue-derived mesenchymal stem cells (ADSCs) or from a 3:1 mixed culture of ADSCs and rabbit Achilles tenocytes. These cell secretomes were examined and compared in terms of their proteomic profiles and biological activities. Applied to a tenocyte

Indexed as

AngiogenesisMesenchymal stem cellsProteomicsSecretomeTendon healingTenocytes

Identifiers

PMID40655991
PMCPMC12246857

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.