Feasibility and effect of an immersive virtual reality-based platform for cognitive training in real-life scenarios in patients with mood - or psychotic disorders: A randomized, controlled proof-of-concept study.

Objectives: Cognitive impairment is common across mood disorders (MD) and psychosis-spectrum disorders (PSD) but there is a lack of real-life pro-cognitive training programmes. Fully immersive virtual reality (VR) has the potential to ensure motivating, engaging cognition training directly relevant to patients' daily lives. This randomized, controlled proof-of-concept study investigated the feasibility and cognitive benefits of short-term VR-assisted training. Methods: Forty patients with MD or PSD were randomized to one week of VR-assisted training (n ​= ​20) or treatment as usual (TAU; n ​= ​20). They were assessed at baseline and after one week with a VR cognition test, neuropsychological tests, and questionnaires regarding user experience. Patients in the training group underwent two VR training sessions in a kitchen environment that involved solving tasks related to planning and cooking a meal using various cognitive strategies. They also completed two home assignments during which they applied the acquired strategies. Results: The completion rate was 100%. Patients reported high enjoyment and moderate-to-high presence in the VR environment and minimal motion sickness. VR training improved the global VR-based cognitive composite score with a large effect size compared with TAU ( Conclusion: VR-assisted cognition training showed high feasibility and improved aspects of cognition after only one week. We therefore plan a larger trial to investigate the cognitive benefits of four-weeks VR-assisted cognition training.