ArticleNeuroscience applied2023
From microRNA to protein, linking the neurotrophic hypothesis of depression to the Wistar Kyoto rat.
Article in Neuroscience applied, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Neuroimaging insights from Wistar-Kyoto rats under chronic mild stress: morphological and metabolic brain correlates of treatment-resistant depression.Scientific reports · 2026Article
- Unraveling psilocybin's therapeutic potential: behavioral and neuroplasticity insights in Wistar-Kyoto and Wistar male rat models of treatment-resistant depression.Psychopharmacology · 2025Article
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5 authors.
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Abstract
Animal models of depression offer an alternative research-platform to clinical studies where limitations such as incomplete medical histories, patient heterogeneity, and difficulty tracking comorbidities leading to depression can be more easily overcome. In that context the Wistar Kyoto (WKY) rat strain has for many years been used as an endogenous model of depression. Here we want to further explore the depressive-like phenotype of the WKY rats to extend its validity as a preclinical model of depression. For this purpose, 49 microRNAs (miRNAs), which have been linked to the neurotrophic hypothesis of depression were selected and their levels were examined in hippocampus, prefrontal cortex, and blood from the WKY rats. Subsequently, miRNA/target mRNA/protein relationships were explored. Seventeen miRNAs across brain and blood exhibited significant regulation (>30%). Fifteen of 17 miRNAs were upregulated in the WKY rats, when compared to the Wistar Hannover Galas rats. This was coupled with general downregulation of corresponding mRNA targets in both brain regions. We observed decreased
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