ArticleJournal of inflammation research2025
Serum Concentrations of Interleukin-8 and Vitamin D Levels in Jordanian Patients with Rheumatoid Arthritis.
Article in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent inflammation. Vitamin D deficiency and elevated levels of IL-8 have been implicated in the pathogenesis of RA. Aims of the Study: This cross-sectional study aims to compare Vitamin D and IL-8 levels between RA patients and healthy controls and assess the relationship between Vitamin D, IL-8, and other inflammatory markers in RA patients. Methodology: The study included 123 participants divided into two groups: 63 RA patients and 60 healthy controls, with equal numbers of males and females in each group. Serum levels of Vitamin D, IL-8, rheumatoid factor (RF), anti-cyclic citrullinated peptide (anti-CCP) antibodies, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and white blood cell (WBC) count were measured and compared between the groups. Results: RA patients had a higher percentage of females (74.6%) compared to the control group (41.7%). Vitamin D levels were significantly lower in RA patients compared to controls (41.4 ± 25.2 vs 46.5 ± 12.4, p = 0.002). IL-8 levels were significantly higher in the RA group compared to controls (546.9 pg/mL vs 3.1 pg/mL, p < 0.001). RF and anti-CCP antibody levels were also significantly higher in RA patients. However, no significant correlation was found between IL-8, Vitamin D, and other inflammatory markers. Conclusion: The findings highlight the importance of Vitamin D screening or intervention in RA patients due to its potential impact on immune function and disease progression. The elevated IL-8 levels and other inflammatory markers confirm the chronic inflammatory state in RA, emphasizing the need for continuous inflammation-targeted approaches, including pharmacological treatment and lifestyle modifications.
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