Evidence map›Paper›PMID 40655949›Full record

ReviewFrontiers in cell and developmental biology2025

Understanding amblyopia from the perspective of neurovascular units: changes in the retina and brain.

Lin Zhang, Yaqi Zhao, Xiaolu Shi, Fan Wu, Yi Shen

Abstract readReview
In one paragraph

Review in Frontiers in cell and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lin ZhangSpecial Education College, Beijing Union University, Beijing, China.
Yaqi ZhaoSpecial Education College, Beijing Union University, Beijing, China.
Xiaolu ShiExperimental Research Center, China Academy of Chinese Medical Sciences, Beijing, China.
Fan WuSpecial Education College, Beijing Union University, Beijing, China.
Yi ShenSpecial Education College, Beijing Union University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As a developmental vision disorder, amblyopia has traditionally been studied with a focus on neurons. However, the neurovascular unit (NVU), a dynamic functional complex of neurons, blood vessels, and glial cells, has recently been implicated in amblyopia. This review systematically discusses the pathological changes and functional interactions of the NVU in retina and brain in amblyopia patients and experimental models, providing a new perspective for clinical intervention.

Indexed as

amblyopiabrainneural plasticityneurovascular unitretina

Identifiers

PMID40655949
PMCPMC12245887

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.