ArticleJournal of biomedical optics2025
Automatic photoacoustic monitoring of perinatal brain hypoxia with superior sagittal sinus detection.
Article in Journal of biomedical optics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Significance: Despite advances in perinatal medicine over decades, perinatal hypoxic-ischemic encephalopathy (HIE) remains a significant cause of fetal cerebral palsy and can lead to other severe medical sequelae or death. Therefore, it is highly desirable to effectively detect brain hypoxia during labor and postnatally for HIE management. Aim: We recently validated the feasibility of transcranial photoacoustic (PA) imaging for oxyhemoglobin saturation measurement at the superior sagittal sinus ( Approach: We proposed a two-step algorithm that focuses on the most informative region of the brain for oxygenation status, the superior sagittal sinus (SSS). First, a convolutional neural network (U-Net) is trained to detect the location of SSS in the coronal cross-section PA images. Then, an optimized region of interest patch around the predicted SSS location is cropped from the spectral unmixed image and averaged as the Results: The algorithm was evaluated on an Conclusions: The proposed automatic
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