SynthesisF1000Research2024
Antimicrobial effect of silver diamine fluoride (SDF) in arresting dentine caries of permanent teeth: A Systematic review.
Synthesis in F1000Research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Antimicrobial effect of silver diamine fluoride (SDF) in arresting dentine caries of permanent teeth: A Systematic review.F1000Research · 2024Pooled it
- Effect of Silver Diamine Fluoride Application Methods on Dentin Microhardness and Durability Under pH Cycling: An In Vitro Study.Clinical and experimental dental research · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Silver diamine fluoride (SDF) is recognized for its potent antibacterial properties and is commonly used in dentistry to treat carious lesions. This review aims to evaluate the antimicrobial effect of SDF on dentine caries in permanent teeth. The objective is to provide a comprehensive analysis of the existing literature to assess the efficacy of SDF in combating cariogenic flora within dentin lesions. Materials and Methods: A systematic electronic search was conducted using Google Scholar, Cochrane Library, and PubMed databases to identify relevant studies published between January 2010 and September 2022. The search strategy focused on retrieving in vitro and in vivo studies assessing the antimicrobial effect of SDF on dentinal caries. The inclusion criteria encompassed studies that compared SDF with other antimicrobial agents, such as sodium fluoride varnish, potassium iodide, silver nitrate, chlorhexidine, plasma jet, and deionized water. The Cochrane Collaboration assessment tool was employed to evaluate the risk of bias in the included studies. Results: Nine studies met the inclusion criteria, consisting of seven in vitro and in situ studies investigating the antimicrobial effect of SDF on dentinal caries, and two in vitro and in vivo studies examining its antibacterial effect on root caries. These studies collectively demonstrated the promising antimicrobial potential of SDF against cariogenic flora present in dentin lesions. However, variations in study design, methodology, and outcome measures were observed across the included studies. Conclusion: The review underscores the significant antimicrobial efficacy of SDF in combating cariogenic bacteria within dentin lesions of permanent teeth. Despite the promising findings, there remains a lack of comprehensive understanding regarding the precise characteristics and mechanisms underlying the antimicrobial action of SDF, particularly concerning nano-silver. Future research, including long-term clinical trials, is warranted to elucidate optimal dosage regimens and therapeutic approaches for the routine application of SDF in managing dental caries.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.