Evidence map›Paper›PMID 40655904›Full record

ArticleCase reports in hematology2025

Successful Treatment of Anemia With Ringed Sideroblasts Induced by Antidepressants Through Vitamin B6 Supplementation and Discontinuation of Antidepressants.

Sanshiro Nakao, Chiaki Nakaseko, Chikako Ohwada, Keisuke Kirito, Asuka Shibamiya, Akane Tanaka, Reiko Watanabe, Naomi Shimizu

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Case reports in hematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sanshiro NakaoDepartment of Hematology, Toho University Medical Center Sakura Hospital, Chiba, Japan.ORCID https://orcid.org/0009-0001-3274-1845
Chiaki NakasekoDepartment of Hematology, International University of Health and Welfare School of Medicine, Chiba, Japan.ORCID https://orcid.org/0000-0003-1175-226X
Chikako OhwadaDepartment of Hematology, International University of Health and Welfare School of Medicine, Chiba, Japan.ORCID https://orcid.org/0000-0001-9648-940X
Keisuke KiritoDepartment of Hematology, International University of Health and Welfare School of Medicine, Chiba, Japan.ORCID https://orcid.org/0009-0005-1416-6436
Asuka ShibamiyaDepartment of Hematology, International University of Health and Welfare School of Medicine, Chiba, Japan.ORCID https://orcid.org/0000-0002-6327-5322
Akane TanakaDepartment of Hematology, International University of Health and Welfare School of Medicine, Chiba, Japan.ORCID https://orcid.org/0009-0006-8510-4176
Reiko WatanabeDepartment of Hematology, International University of Health and Welfare School of Medicine, Chiba, Japan.ORCID https://orcid.org/0000-0003-4655-4407
Naomi ShimizuDepartment of Hematology, Toho University Medical Center Sakura Hospital, Chiba, Japan.ORCID https://orcid.org/0000-0001-8295-8893

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vitamin B6 (VB6) is a vital coenzyme for δ-aminolevulinic acid synthase (ALAS) in heme biosynthesis. We report a 49-year-old male with severe microcytic anemia and ringed sideroblasts initially diagnosed as myelodysplastic syndrome (MDS). VB6 deficiency, attributed to long-term amoxapine use, was identified. His anemia improved significantly with VB6 supplementation and resolved completely after discontinuing amoxapine. This case highlights the need to consider VB6 deficiency in anemia with ringed sideroblasts.

Indexed as

antidepressantsmyelodysplastic syndromeringed sideroblastssideroblastic anemiavitamin B6 deficiency

Identifiers

PMID40655904
PMCPMC12255493

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.