ArticleJournal of pharmacy & bioallied sciences2025
Comparative Efficacy of Tranexamic Acid and Vitamin C with Microneedling: A Split-Face Study in Melasma Management.
Article in Journal of pharmacy & bioallied sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy and safety of microneedling with tranexamic acid versus microneedling with vitamin C in the treatment of melasma: a systematic review and meta-analysis.Journal of medicine and life · 2026Pooled it
- Targeting Melasma: Innovations in Pigment Deposition and Photoaging in Cosmetic Dermatology.Journal of cosmetic dermatology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Melasma is a common pigmentary disorder, primarily affecting women with Fitzpatrick skin types IV-VI. It presents as symmetric hyperpigmented macules and patches on the face. While hydroquinone and triple combination creams are standard treatments, tranexamic acid (TXA) and vitamin C delivered via microneedling have shown promising results in recent studies. Objective: To assess the efficacy and safety of combining TXA or vitamin C with microneedling in treating melasma in females. Material and Methods: A prospective, split-face comparative study included ten female patients (20 vertical split faces) with melasma from a tertiary care center. Both sides of the face underwent microneedling with a Dermapen (16-needle cartridge, 1.5 mm length). Pre-microneedling, vitamin C serum was applied on one side, while on the other side, TXA was applied. The same procedure was done three times at 0, 4, and 8 weeks. Statistical analysis employed Chi-square, paired Results: Both groups demonstrated significant improvement in mMASI scores and percentage response after treatment. Conclusion: TXA and vitamin C combined with microneedling are effective and safe for melasma, offering promising therapeutic outcomes.
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Registered trials
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