Evidence map›Paper›PMID 40655745›Full record

ReviewJournal of pharmacy & bioallied sciences2025

Unlocking Healing: Ozone Therapy's Breakthrough in Oral Lesion Management - A Narrative Review.

Nishath Sayed Abdul, Atheer A Almughaiseeb, Sara M Alghannam, Ali B Alshaikh

Registry-linked trialAbstract readReview
In one paragraph

Review in Journal of pharmacy & bioallied sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07517328 (The Effect of Adjunctive Gaseous Ozone Therapy on Wound Healing After Gingivectomy/Gingivoplasty in Patients With Chronic Inflammatory Gingival Enlargement), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07517328 nacompletednot on this map

The Effect of Adjunctive Gaseous Ozone Therapy on Wound Healing After Gingivectomy/Gingivoplasty in Patients With Chronic Inflammatory Gingival Enlargement: A Randomized Split-Mouth Clinical Trial

TypeinterventionalSponsorAtaturk UniversityRan2016 to 2026Enrolled24ConditionsChronic Inflammatory Gingival Enlargement, Gingival Enlargement, Gingival HyperplasiaArmsGaseous ozone application, Gingivectomy/gingivoplasty
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nishath Sayed AbdulDepartment of OMFS and Diagnostic Sciences, College of Medicine and Dentistry, Riyadh Elm University, Riyadh, Saudi Arabia.
Atheer A AlmughaiseebSaudi Board of Paediatric Dentistry, Riyadh Elm University, College of Medicine and Dentistry, Riyadh, Saudi Arabia.
Sara M AlghannamSaudi Board of Paediatric Dentistry, National Guard Hospital, Eastern Region, Saudi Arabia.
Ali B AlshaikhSaudi Board of Paediatric Dentistry, Riyadh Elm University, College of Medicine and Dentistry, Riyadh, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ozone therapy, a versatile and potent treatment option, is garnering attention for its efficacy in managing various oral lesions. By conducting a comprehensive literature search without timeline restrictions across databases such as PubMed, Scopus, and Web of Science, this review synthesizes findings from randomized controlled trials, cohort studies, and significant case reports. The results indicate that ozone therapy effectively reduces microbial load, enhances wound healing, and alleviates pain, thereby improving overall treatment outcomes. This review compares ozone therapy to traditional treatment modalities, highlighting its potential for reducing dependence on pharmacological treatments due to its minimal side effects and significant efficacy. The integration of ozone therapy into mainstream dental practices is discussed, along with the barriers such as regulatory issues and the need for further research.

Indexed as

Antimicrobial effectsimmunomodulatory effectsoral lesionsozone therapywound healing

Identifiers

PMID40655745
PMCPMC12244659

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.