ArticleJournal of pharmacy & bioallied sciences2025
Evaluation of Novel Calcium Silicate-Based Sealers Reinforced with Bioactive Glass.
Article in Journal of pharmacy & bioallied sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Effect of calcium silicate and epoxy resin-based sealers on postoperative pain: a randomized clinical trial.BMC oral health · 2026Trial
- Review
- Bridging the Break: Three Approaches to Root Fracture Management Using Bioactive Glass Material, Fiber Post, and Orthodontic Stabilization: A Case Series.Iranian endodontic journal · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Calcium silicate-based sealers have gained significant attention in endodontics due to their biocompatibility, bioactivity, and sealing ability. Incorporating bioactive glass into these sealers could potentially enhance their physicochemical and biological properties, providing improved clinical outcomes. Materials and Methods: Three experimental sealer groups were prepared: group A (calcium silicate-based sealer without reinforcement), group B (calcium silicate-based sealer with 10% bioactive glass), and group C (calcium silicate-based sealer with 20% bioactive glass). The sealers were assessed for their setting time, compressive strength, solubility, and bioactivity. Bioactivity was evaluated by immersing the sealers in simulated body fluid and analyzing hydroxyapatite formation using scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDS). Statistical analysis was conducted using ANOVA with a significance level of Results: Group C demonstrated the shortest setting time (20 ± 1.5 minutes) compared to group B (25 ± 1.2 minutes) and group A (30 ± 1.8 minutes). Compressive strength was significantly higher in group C (80 ± 5 MPa) than in group B (65 ± 4 MPa) and group A (50 ± 3 MPa). Solubility was lowest in group C (2.5 ± 0.3%) and highest in group A (4.5 ± 0.4%). SEM and EDS analysis revealed a greater formation of hydroxyapatite on the surface of group C, indicating superior bioactivity. Conclusion: The addition of bioactive glass to calcium silicate-based sealers significantly improved their mechanical properties, reduced solubility, and enhanced bioactivity. The findings suggest that these reinforced sealers could be promising candidates for endodontic applications, providing improved long-term sealing and biological outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.