ArticleClinical, cosmetic and investigational dermatology2025
Investigating the Impact of Circulating Immune Cells on Acne Using Mendelian Randomization.
Article in Clinical, cosmetic and investigational dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: While growing evidence suggests the intricate relationship between immune cells and the pathogenesis of acne, the causative implications underlying these associations remain poorly characterized. This study aimed to elucidate the causal links between various immune cell phenotypes and the development of acne using Mendelian randomization (MR) analysis. Methods: Leveraging data of 731 immune cell traits and acne from genome-wide association studies, we conducted a bidirectional MR analysis. Rigorous instrumental variables selection was followed by causal inference using five complementary methods, including MR-Egger, weighted median, simple mode, inverse variance weighted (IVW), and weighted mode methods. Heterogeneity and pleiotropy were evaluated using Cochran's Q test, MR-Egger intercept test, and leave-one-out analysis. Results: Genetically predicted alterations in 26 immune cell phenotypes demonstrated causal associations with acne risk. Notably, 18 immune cell types exhibited protective effects, such as CD25 on IgD+ (IVW: OR 0.922, 95% CI 0.868-0.979; Conclusion: In conclusion, this research provides compelling genetic evidence for causal immunomodulatory influences on acne development, thus laying the groundwork for future investigational efforts aimed at uncovering targeted therapeutic strategies in acne management.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.