Evidence map›Paper›PMID 40655364›Full record

ArticleIndian journal of microbiology2025

Comprehensive Genomic, Mutation, Phylogenetic, and Statistical Analysis of the Monkeypox Virus Across Multiple Countries.

Imran Zafar, Faheem Kanwal, Muhammad Azmat, Ahsanullah Unar, Ijaz Ali, Waqas Yousaf, Qurat Ul Ain, Mohd Ashraf Rather, Nemat Ali, Mohammad Rashid Khan and 2 more

Abstract read
In one paragraph

Article in Indian journal of microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Imran ZafarDepartment of Biochemistry and Biotechnology, Faculty of Science, The University of Faisalabad (TUF), Faisalabad, Pakistan.
Faheem KanwalInstitute of Molecular Biology and Biotechnology (IMBB), University of Lahore, Lahore, Pakistan.
Muhammad AzmatInstitute of Molecular Biology and Biotechnology (IMBB), University of Lahore, Lahore, Pakistan.
Ahsanullah UnarDepartment of Precision Medicine, University of Campania 'L. Vanvitelli', Naples, Italy.
Ijaz AliCentre for Applied Mathematics and Bioinformatics (CAMB), Gulf University for Science and Technology, Hawally, Kuwait.
Waqas YousafDepartment of Botany, Institute of Molecular Biology and Biotechnology, The University of Lahore, Lahore, Punjab Pakistan.
Qurat Ul AinDepartment of Chemistry, Government College Women University, Faisalabad, Pakistan.
Mohd Ashraf RatherDivision of Fish Genetics and Biotechnology, Faculty of Fisheries, Rangil-Gandarbal (SKAUST-K), Ganderbal, India.
Nemat AliDepartment of Pharmacology and Toxicology, College of Pharmacy, King Saud University, 11451 Riyadh, Saudi Arabia.
Mohammad Rashid KhanDepartment of Pharmacology and Toxicology, College of Pharmacy, King Saud University, 11451 Riyadh, Saudi Arabia.
Amandeep Singh DhanjuDepartment of Agriculture, Khalsa College Ghardiwala, Hoshiarpur, 144207 India.
Rohit SharmaDepartment of Rasa Shastra and Bhaishajya Kalpana, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh 221005 India.ORCID 0000-0002-3682-3573

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Our study offers a comprehensive Monkeypox virus (MPXV) analysis, utilizing innovative protocols to uncover potential vulnerabilities. We examine MPXV's epidemiology, link to smallpox, genomics, mutation landscape, clinical features, diagnostics, therapeutics, FDA-approved drugs, clinical trials, and preventive strategies. We used various analytical methods to analyse genome data from the NCBI database (2019-2023) to assess sequence alignment, protein identification, and genome diversity. The phylogenomic analysis identified unique lineages and a mutation associated with human transmission, revealing that 24 MPXV proteins are particularly mutation-prone. Domain analysis confirmed conserved Ortho-poxvirus genes and critical regions, providing insights into MPXV's structure, diversity, and host interaction. Additionally, we integrated clinical data, geospatial mapping, statistical analysis, and AI/ML for predictive insights on MPXV progression. We also explored bioinformatics tools and plant-based treatments, conducting in-silico studies to identify potential drug targets. Our research integrates epidemiological and genomic data to inform real-time preventive measures and optimize public health responses to MPXV.

Indexed as

Genome wide identificationMonkeypox virusMPXVMutation analysisPhylogeny

Identifiers

PMID40655364
PMCPMC12246335

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.