Evidence map›Paper›PMID 40655258›Full record

ArticleJournal of experimental orthopaedics2025

Preoperative anxiety differentiates post-surgical opioid use in patients undergoing anterior cruciate ligament reconstruction.

Brittany L Nelson, Shayla M Warren, Thea Xeroegeanes, Taylor M Zuleger, Ajay Premkumar, Gregory D Myer, Susmita Kashikar-Zuck, Jed A Diekfuss

Abstract read
In one paragraph

Article in Journal of experimental orthopaedics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Brittany L NelsonEmory Sports Performance And Research Center (SPARC) Flowery Branch Georgia USA.ORCID https://orcid.org/0000-0001-6070-0322
Shayla M WarrenEmory Sports Performance And Research Center (SPARC) Flowery Branch Georgia USA.ORCID https://orcid.org/0000-0003-2950-3819
Thea XeroegeanesUndergraduate Pre-Nursing Studies University of Arkansas Fayetteville Arkansas USA.
Taylor M ZulegerEmory Sports Performance And Research Center (SPARC) Flowery Branch Georgia USA.ORCID https://orcid.org/0000-0002-4622-4005
Ajay PremkumarDepartment of Orthopaedics Emory University School of Medicine Atlanta Georgia USA.ORCID https://orcid.org/0000-0003-1080-8655
Gregory D MyerEmory Sports Performance And Research Center (SPARC) Flowery Branch Georgia USA.ORCID https://orcid.org/0000-0002-9983-8422
Susmita Kashikar-ZuckDepartment of Pediatrics University of Cincinnati College of Medicine Cincinnati Ohio USA.
Jed A DiekfussEmory Sports Performance And Research Center (SPARC) Flowery Branch Georgia USA.ORCID https://orcid.org/0000-0003-3835-363X

Funding

Pediatric musculOskeletal & RheumaTology Innovation COre center (PORTICO)P30AR076316 · NIAMS · CINCINNATI CHILDRENS HOSP MED CTR · PI BRUNNER, HERMINE I · 2019 to 2023
$3.4M
NIAMS NIH HHS P30 AR076316
6 · The paper itself

Abstract

Purpose: Opioids prescribed to reduce pain and aid in recovery following anterior cruciate ligament reconstruction (ACLR) may pose a risk of future substance use disorder. The purpose of this study was to determine if pre-operative anxiety and depression differentiated opioid intake following ACLR. The contribution of sex, age, and graft type to post-operative opioid usage was also explored. Methods: Data from 237 participants ( Results: Patients took an average of one opioid pill daily. Females with pre-operative anxiety reported significantly greater post-operative opioid intake ( Conclusion: Anxiety, but not depression, was a risk factor for elevated opioid use in females undergoing ACLR. Interestingly, opioid intake between males and females, as well as by age and graft type, were comparable overall, indicating the unique influence of psychological rather than biological or demographic factors on opioid use following ACLR. Clinicians should consider biopsychosocial assessments to support preoperative opioid counselling, particularly in females with anxiety undergoing ACLR. Level of Evidence: Level IV.

Indexed as

opioid usepatient anxietypost‐ACLR recoverysubstance use disorder

Identifiers

PMID40655258
PMCPMC12255945

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.