ArticleJournal of mood and anxiety disorders2025
A randomized controlled trial of computerized cognitive training to improve working memory in individuals with elevated repetitive negative thinking: Behavioral and neural outcomes.
Article in Journal of mood and anxiety disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Repetitive negative thinking is associated with conflict-related neural activity that modulates evidence accumulation.Journal of mood and anxiety disorders · 2026Article
- The association between childhood maltreatment and neural functioning during a working memory task in adults with internalizing disorders.Brain imaging and behavior · 2026Article
- Effects of violence on executive function: a neuropsychological and predictive analysis in victims of the armed conflict in Colombia.Frontiers in human neuroscience · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Individuals with mood, anxiety, and traumatic stress disorders frequently experience distressing repetitive negative thinking (RNT) symptoms, which are characterized by pervasive, uncontrollable negative thoughts. Dysfunction in executive functioning processes, particularly the ability to regulate the contents of working memory, are implicated in the development and maintenance of RNT. Guided by the National Institute of Mental Health experimental therapeutics framework, this study aimed to investigate the cognitive effects and effects of two doses of a novel working memory training (WMT) intervention in individuals with elevated RNT across mood, anxiety, and traumatic stress disorders. We conducted a three-arm randomized controlled trial with 8-session and 16-session WMT interventions and a waitlist control group (N = 73). Our primary goal was to establish target engagement of WMT as measured by behavioral and neural indicators of working memory performance. Results revealed that WMT significantly improved working memory performance and resulted in reduced frontoparietal neural activity during a working memory task compared to the waitlist control group, providing evidence of target engagement. Exploratory analyses revealed a potential transfer of training effects to fluid intelligence, a construct related to but distinct from working memory, suggesting broader cognitive benefits of WMT. These data provide evidence that WMT can enhance working memory performance in individuals with RNT. This intervention holds promise as a transdiagnostic approach for ameliorating RNT-related clinical burden, with the 8-session regimen showing pragmatic advantages. Further research is needed to elucidate its impact on clinical symptoms and explore potential cognitive benefits beyond working memory.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.