ReviewFrontiers in immunology2025
A bibliometric analysis of immune escape in colorectal cancer: research trends, key contributors, and future directions.
Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- TSC1 deficiency drives immune evasion in colorectal cancer via mTORC1-mediated dysregulation of PD-L1 sialylation.Frontiers in immunology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Colorectal cancer (CRC) has brought a serious disease burden to the whole world. Immune escape not only promotes the growth and metastasis of CRC, but also limits the effect of immunotherapy. The purpose of this study is to clarify the research status of immune escape in CRC through bibliometrics. Methods: This analysis examined publications on immune escape in CRC from the Web of Science Core Collection. The time limit is 2015-2024. After searching and screening by two researchers, data were collected and various analysis were conducted using tools such as VOSviewer, CiteSpace, and bibliometrix. By analyzing the large-scale existing literature data and using the quantitative method of bibliometric analysis, the research trends and emerging topics can be effectively identified. Results: A total of 573 articles and reviews were included. From 2015-2024, the annual growth rate of 15.93%. The research from China is the most (50.09%), but the research from the United States and Germany is cited more times. Frontiers in Immunology has published the most articles (6.46%). Lei Wang and Peter J.K. Kuppen have made notable contributions, with substantial international collaboration. Keyword analysis highlights research hotspots such as tumor microenvironment and immune-related signaling pathways. Conclusion: The latest research status of immune escape in CRC is shown. Understanding the immune escape mechanism is very important for understanding the occurrence and development of CRC and developing effective immunotherapy strategies. Future research directions include integrating multiple databases to reduce biases inherent in single-database analyses and employing machine learning methods to predict emerging research hotspots, thus providing actionable insights into the dynamic landscape of immune escape research in CRC.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.