ReviewFrontiers in immunology2025
Histone variants: key regulators of inflammation in cell dedifferentiation and transdifferentiation.
Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- H2A.J is an epigenetic driver of IL-17-associated inflammation in TMolecular biomedicine · 2026Article
- Leukemic Transdifferentiation: From Pathological Plasticity to Dendritic Cell-Based Immunotherapy.Biomedicines · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Histone variants are specialized isoforms of histone proteins that play crucial roles in regulating chromatin structure and function, influencing transcription, DNA repair, and cell cycle progression. Their dynamic incorporation into nucleosomes impacts gene expression and cellular identity, particularly in the context of inflammation during cell dedifferentiation and transdifferentiation. This mini-review provides a comprehensive overview of the role of histone variants in these processes, highlighting their significance in modulating inflammatory responses and cellular plasticity. We discuss mechanisms by which histone variants influence chromatin architecture and gene regulation, the interplay between histone variants and inflammatory pathways, and the specific roles of key histone variants such as H3.3, H2A.Z, and MacroH2A in dedifferentiation and transdifferentiation. Additionally, we explore the potential therapeutic implications of targeting histone variants to modulate inflammation and cellular plasticity in diseases like cancer and chronic inflammatory conditions. By summarizing existing knowledge and identifying gaps in understanding, this review underscores the importance of histone variants in inflammation-related cell plasticity and suggests future research directions further elucidating their roles and therapeutic potential.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.