Evidence map›Paper›PMID 40655146›Full record

ArticleFrontiers in immunology2025

Identification and analysis of cuproptosis associated molecular clusters and immunological profiles in atopic dermatitis.

Liangzhe Wang, Bo Wang, Min Peng, Xiaoyan Yang, Sijia Huang, Ruixin Wang, Lin Du, Ruiqian Yao, Wei Wang, Baiping Dong and 1 more

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PubMed Full text at PMC Publisher
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Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Liangzhe Wang *Department of Dermatology, Naval Medical Center, Naval Medical University, Shanghai, China.
Bo Wang *Department of Dermatology, Naval Medical Center, Naval Medical University, Shanghai, China.
Min Peng *Department of Ultrasound Diagnosis, Naval Medical Center, Naval Medical University, Shanghai, China.
Xiaoyan YangDepartment of Dermatology, Naval Medical Center, Naval Medical University, Shanghai, China.
Sijia HuangSchool of Medicine, Shanghai University, Shanghai, China.
Ruixin WangDepartment of Dermatology, Naval Medical Center, Naval Medical University, Shanghai, China.
Lin DuDepartment of Dermatology, Naval Medical Center, Naval Medical University, Shanghai, China.
Ruiqian YaoDepartment of Dermatology, Naval Medical Center, Naval Medical University, Shanghai, China.
Wei WangDepartment of Research, Naval Medical Center, Naval Medical University, Shanghai, China.
Baiping DongDepartment of Dermatology, Naval Medical Center, Naval Medical University, Shanghai, China.
Yuanjie ZhuDepartment of Dermatology, Naval Medical Center, Naval Medical University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Atopic dermatitis (AD) is a chronic skin condition marked by persistent itching and dryness. The role of cuproptosis, a novel form of programmed cell death, in AD is not yet understood. Methods: The GSE107361 dataset was obtained from the Gene Expression Omnibus (GEO) database. Cuproptosis-related genes (CRGs) in AD were identified and analyzed, and immune landscape analysis was performed using ssGSEA. AD was clustered based on CRGs using ConsensusClusterPlus. Weighted gene co-expression network analysis (WGCNA) and differential gene expression analysis were conducted. Hub genes between AD clusters were identified, and both protein-protein interaction (PPI) and drug-gene interaction networks were developed. Results: Three CRGs (DLD, MTF1, and GLS) were significantly upregulated in the AD group compared to healthy controls. Notably, four core CRGs (LIAS, LIPT1, PDHA1, CDKN2A) distinguished early-onset from adult-onset AD, indicating more active cuproptosis in early-onset AD. CRGs were linked to immune cell infiltration in AD, highlighting differences in immune microenvironments between early- and adult-onset AD. Early-onset AD showed high innate immunity, while adult-onset AD had a mix of innate and type 1 adaptive immunity. CRG expression identified two molecular subtypes with distinct immune infiltration: Cluster 2 (high cuproptosis) had predominant innate immunity, while Cluster 1 (low cuproptosis) had adaptive immunity. Additionally, 102 hub DEGs were identified through WGCNA co-expression network analysis, and 10 hub node genes were identified and potential drugs were explored for the management of AD. Conclusions: The study provides insights into the roles of cuproptosis-related processes in the pathogenesis and potential treatment of AD. Finding of key hub genes between the 2 distinct immune infiltration subtypes might inform potential therapeutic strategies for AD.

Indexed as

Dermatitis, AtopicAdultComputational BiologyDatabases, GeneticGene Expression ProfilingGene Regulatory NetworksHumansImmunity, InnateProtein Interaction MapsTranscriptomeatopic dermatitisbioinformaticscuproptosisdifferentially expressed genesimmune infiltration

Identifiers

PMID40655146
PMCPMC12245679

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