Evidence map›Paper›PMID 40655029›Full record

ArticlebioRxiv : the preprint server for biology2025

Molecular mechanism of exchange coupling in CLC chloride/proton antiporters.

Deniz Aydin, Chih-Ta Chien, Jürgen Kreiter, Amy Nava, Jasmina M Portasikova, Lukas Fojtik, Catalina Mosquera Salcedo, Petr Man, Ron O Dror, Wah Chiu and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Deniz AydinStanford University, Department of Molecular and Cellular Physiology.
Chih-Ta ChienDepartment of Bioengineering and Department of Microbiology and Immunology, Stanford University, Stanford, 94305.
Jürgen KreiterStanford University, Department of Molecular and Cellular Physiology.
Amy NavaStanford University, Department of Molecular and Cellular Physiology.
Jasmina M PortasikovaDepartment of Biochemistry, Faculty of Science, Charles University, Hlavova 2030/8, 128 43, Prague 2, Czech Republic.
Lukas FojtikDepartment of Biochemistry, Faculty of Science, Charles University, Hlavova 2030/8, 128 43, Prague 2, Czech Republic.
Catalina Mosquera SalcedoStanford University, Department of Molecular and Cellular Physiology.
Petr ManInstitute of Microbiology of the Czech Academy of Sciences, Division BioCeV, Prumyslova 595, 252 50 Vestec, Czech Republic.
Ron O DrorStanford University, Department of Molecular and Cellular Physiology.
Wah ChiuDepartment of Bioengineering and Department of Microbiology and Immunology, Stanford University, Stanford, 94305.ORCID 0000-0002-8910-3078
Merritt MadukeStanford University, Department of Molecular and Cellular Physiology.ORCID 0000-0001-7787-306X

Funding

The Stanford-SLAC CryoEM Center supplementU24GM129541 · NIGMS · STANFORD UNIVERSITY · PI CHIU, WAH, HEDMAN, BRITT · 2018 to 2023
$54.8M
Mechanisms of CLC Transporters and Channels:R01GM113195 · NIGMS · STANFORD UNIVERSITY · PI MADUKE, MERRITT C · 2016 to 2024
$4.0M
NIGMS NIH HHS R01 GM113195NIGMS NIH HHS U24 GM129541
6 · The paper itself

Abstract

The ubiquitous CLC membrane transporters are unique in their ability to exchange anions for cations. Despite extensive study, there is no mechanistic model that fully explains their 2:1 Cl

Identifiers

PMID40655029
PMCPMC12248016

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.