Evidence map›Paper›PMID 40655013›Full record

ArticlebioRxiv : the preprint server for biology2025

Reversion of a RND transporter pseudogene uncovers latent stress resistance in

Thomas Kim, Bongjin Hong, Thomas V O'Halloran, Erika Lisabeth, Richard R Neubig, Aretha Fiebig, Sean Crosson

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Thomas KimDepartment of Microbiology, Genetics & Immunology, Michigan State University, East Lansing, MI, USA.
Bongjin HongDepartment of Microbiology, Genetics & Immunology, Michigan State University, East Lansing, MI, USA.ORCID 0000-0003-2992-9617
Thomas V O'HalloranDepartment of Microbiology, Genetics & Immunology, Michigan State University, East Lansing, MI, USA.ORCID 0000-0001-8732-5059
Erika LisabethDepartment of Pharmacology & Toxicology, Michigan State University, East Lansing, MI, USA.ORCID 0000-0002-4560-3345
Richard R NeubigDepartment of Pharmacology & Toxicology, Michigan State University, East Lansing, MI, USA.ORCID 0000-0003-0501-0008
Aretha FiebigDepartment of Microbiology, Genetics & Immunology, Michigan State University, East Lansing, MI, USA.ORCID 0000-0002-0612-5029
Sean CrossonDepartment of Microbiology, Genetics & Immunology, Michigan State University, East Lansing, MI, USA.ORCID 0000-0002-1727-322X

Funding

TR&D Project 3: Photoacoustic Detection of Metal Fluxes at the Tissue LevelP41GM135018 · NIGMS · NORTHWESTERN UNIVERSITY · PI MACRENARIS, KEITH W · 2020 to 2024
$5.8M
Metalloregulation by MerR and Fur Protein FamiliesR01GM038784 · NIGMS · NORTHWESTERN UNIVERSITY · PI O'HALLORAN, THOMAS V · 1992 to 2025
$3.5M
Regulation of the Brucella abortus general stress responseR01AI177619 · NIAID · MICHIGAN STATE UNIVERSITY · PI Sean Crosson · 2024 to 2026
$1.5M
NIAID NIH HHS R01 AI177619NIGMS NIH HHS P41 GM135018NIGMS NIH HHS R01 GM038784
6 · The paper itself

Abstract

Small-molecule screens can advance therapeutic discovery while yielding new insights into pathogen biology. Through a luminescence-based screen, we identified clinically approved dihydropyridines that reduced the fitness of the intracellular pathogen

Identifiers

PMID40655013
PMCPMC12248096

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.