Evidence map›Paper›PMID 40655012›Full record

ArticlebioRxiv : the preprint server for biology2025

Elizabeth M DiLoreto, Xavier Gonzalez, Khursheed A Wani, Jiali Shen, Javier E Irazoqui, Jagan Srinivasan

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Elizabeth M DiLoretoDepartment of Biology and Biotechnology, Worcester Polytechnic Institute, Worcester, MA, United States.
Xavier GonzalezDepartment of Microbiology, UMass Chan Medical School, Worcester, MA, United States.ORCID 0000-0001-5546-8856
Khursheed A WaniDepartment of Microbiology, UMass Chan Medical School, Worcester, MA, United States.
Jiali ShenDepartment of Microbiology, UMass Chan Medical School, Worcester, MA, United States.
Javier E IrazoquiDepartment of Microbiology, UMass Chan Medical School, Worcester, MA, United States.ORCID 0000-0001-6553-1329
Jagan SrinivasanDepartment of Biology and Biotechnology, Worcester Polytechnic Institute, Worcester, MA, United States.ORCID 0000-0001-5449-7938

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Role of MiT Transcription Factors in Host Defense Against Bacterial InfectionR01GM101056 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI IRAZOQUI, JAVIER ELBIO · 2012 to 2022
$3.9M
Innate Immunity Training ProgramT32AI095213 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SILVERMAN, NEAL · 2011 to 2025
$2.5M
Mechanisms of the gut-brain axis that regulate innate immunityR35GM149284 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Javier Elbio Irazoqui · 2023 to 2026
$1.7M
Enhancing the success of underrepresented students in the biomedical sciencesR25GM113686 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LAPANE, KATE L, LEWIS, BRIAN C · 2015 to 2019
$1.7M
Functional connectome of sex-specific processing of social cuesR01DC016058 · NIDCD · WORCESTER POLYTECHNIC INSTITUTE · PI SRINIVASAN, JAGAN · 2017 to 2021
$1.6M
NIAID NIH HHS T32 AI095213NIDCD NIH HHS R01 DC016058NIGMS NIH HHS R01 GM101056NIGMS NIH HHS R25 GM113686NIGMS NIH HHS R35 GM149284NIH HHS P40 OD010440
6 · The paper itself

Abstract

Background: In all animals, the nervous system senses microbial signals to influence host defense. Despite emerging as important sensors of infection to regulate immunity and inflammation, the mechanisms by which pain-sensing nociceptor neurons can detect infections are poorly defined. Using Results: Conclusions: Collectively, these findings reveal that nociceptor neurons lose functional and morphological integrity during infection with

Indexed as

ASH neuronC. elegansinfectionnociceptorsS. aureus

Identifiers

PMID40655012
PMCPMC12247897

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.