ArticlebioRxiv : the preprint server for biology2025
Ectodysplasin overexpression reveals spatiotemporally dynamic tooth formation competency in stickleback and zebrafish.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Organ initiation is often driven by extracellular signals that activate precursor cells competent to receive and respond to the signal, yet little is known about how dynamic competency is in space and time during development. Teeth are excellent organs to study organ initiation competency because they can be activated with the addition of a single signaling ligand, Ectodysplasin (Eda). Eda, a Tumor Necrosis Factor (TNF) ligand, is a critical regulator of ectodermal organ development, including teeth, acting through TNF receptors, like Edar, to activate NF-κB signaling in tooth precursor cells. While Eda is both necessary for normal tooth formation and sufficient for ectopic tooth formation, the spatial and temporal dynamics of competency for ectopic tooth initiation and maintenance remains unknown. To investigate the role of Eda in tooth specification, we generated transgenic sticklebacks and zebrafish with heat shock-inducible
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