Evidence map›Paper›PMID 40654950›Full record

ArticlebioRxiv : the preprint server for biology2025

BRAF

Melanie Angelina Dacheux, Meng-Jung Wu, Michael T Scherzer, Monique Nillson, Brandon Murphy, Sophia Schuman, Zhenlin Ju, Trever Bivona, Piro Lito, Matthew Gumbleton and 9 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Melanie Angelina DacheuxDepartment of Genetics, University of Texas MD Anderson Cancer Center, Houston, Texas.
Meng-Jung WuDepartment of Genetics, University of Texas MD Anderson Cancer Center, Houston, Texas.
Michael T ScherzerHuntsman Cancer Institute, University of Utah, Salt Lake City, Utah.
Monique NillsonDepartment of Thoracic Head & Neck Medical Oncology University of Texas Cancer Center, Houston, Texas.
Brandon MurphyHuntsman Cancer Institute, University of Utah, Salt Lake City, Utah.
Sophia SchumanHuntsman Cancer Institute, University of Utah, Salt Lake City, Utah.
Zhenlin JuDepartment of Bioinformatics and Computational Biology, University of Texas MD Anderson Cancer Center, Houston, Texas.
Trever BivonaDepartment of Medicine, Division of Hematology and Oncology, University of California San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco, California.
Piro LitoHuman Oncology and Pathogenesis Program and the Department of Medicine, Memorial Sloan Kettering, New York, New York.
Matthew GumbletonDepartment of Internal Medicine, University of Utah, Salt Lake City, Utah.
Sonam PuriDepartment of Internal Medicine, University of Utah, Salt Lake City, Utah.
Wallace AkerleyDepartment of Internal Medicine, University of Utah, Salt Lake City, Utah.
Jing WangDepartment of Bioinformatics and Computational Biology, University of Texas MD Anderson Cancer Center, Houston, Texas.
Kaiwen WangDivision of Pharmacy, University of Texas MD Anderson Cancer Center, Houston, Texas.
John HeymachDepartment of Thoracic Head & Neck Medical Oncology University of Texas Cancer Center, Houston, Texas.
Conan G KinseyHuntsman Cancer Institute, University of Utah, Salt Lake City, Utah.
Marcelo NegraoDepartment of Thoracic Head & Neck Medical Oncology University of Texas Cancer Center, Houston, Texas.
Martin McMahonHuntsman Cancer Institute, University of Utah, Salt Lake City, Utah.
Aria VaishnaviDepartment of Genetics, University of Texas MD Anderson Cancer Center, Houston, Texas.

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DIANE BODURKA · 1985 to 2026
$290.8M
UTAH REGIONAL CANCER CENTERP30CA042014 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jared P Rutter · 1986 to 2026
$72.6M
Studying the initiation, progression and therapy of lung cancer in mouse modelsR01CA131261 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI MARTIN MCMAHON · 2009 to 2026
$5.3M
Elucidating the role of support signaling in promoting minimal residual disease in mouse models of oncogene-driven lung cancerR00CA246084 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI VAISHNAVI, ARIA · 2023 to 2025
$741k
Functional Proteomics by Reverse Phase Protein Array in CancerR50CA221675 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LU, YILING · 2017 to 2021
$726k
Elucidating the role of support signaling in promoting minimal residual disease in mouse models of oncogene-driven lung cancerK99CA246084 · NCI · UNIVERSITY OF UTAH · PI VAISHNAVI, ARIA · 2020 to 2022
$347k
Elucidating tumor progression factors in MAPK-driven lung cancersF32CA228267 · NCI · UNIVERSITY OF UTAH · PI VAISHNAVI, ARIA · 2018 to 2019
$80k
NCI NIH HHS F32 CA228267NCI NIH HHS K99 CA246084NCI NIH HHS P30 CA016672NCI NIH HHS P30 CA042014NCI NIH HHS R00 CA246084NCI NIH HHS R01 CA131261NCI NIH HHS R50 CA221675
6 · The paper itself

Abstract

Secretion of ligands of the human epidermal growth factor (EGFR) family of receptors or erythroblastic leukemia viral oncogene family (ERBB1-4) is a feature common to many cancer cells. However, our understanding of the role of autocrine ligands in the aberrant behavior of cancer remains incomplete. Here we demonstrate that, in numerous preclinical models of lung tumorigenesis, BRAF

Indexed as

BRAFV600E oncoprotein kinaseERBB/EGFR signalingGenetically engineered mouse models of lung cancerPathway-targeted therapy

Identifiers

PMID40654950
PMCPMC12248061

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.