Evidence map›Paper›PMID 40654949›Full record

ArticlebioRxiv : the preprint server for biology2025

Concurrent detection of chemically modified bases in yeast mitochondrial tRNAs by Nanopore direct RNA sequencing.

Julia L Reinsch, David M Garcia

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Julia L ReinschInstitute of Molecular Biology, University of Oregon, Eugene, OR, 97403, USA.ORCID 0009-0004-6102-6594
David M GarciaInstitute of Molecular Biology, University of Oregon, Eugene, OR, 97403, USA.ORCID 0000-0003-0600-9527

Funding

Prion-based regulation of RNA-modifying enzyme activitiesR35GM143125 · NIGMS · UNIVERSITY OF OREGON · PI GARCIA, DAVID M. · 2021 to 2025
$1.9M
Graduate Training Grant in GeneticsT32GM149387 · NIGMS · UNIVERSITY OF OREGON · PI Karen J Guillemin · 2023 to 2026
$1.6M
MFB: Integrating LC-MS/MS and Nanopore Sequencing Platforms to Enable the Direct and Quantatative Detection of RNA ModificationsR01HG013876 · NHGRI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Kristin S Koutmou · 2024 to 2026
$1.2M
NHGRI NIH HHS R01 HG013876NIGMS NIH HHS R35 GM143125NIGMS NIH HHS T32 GM149387
6 · The paper itself

Abstract

Mutations in tRNA-modifying enzymes are associated with severe mitochondrial disease in humans.

Identifiers

PMID40654949
PMCPMC12247881

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.