Evidence map›Paper›PMID 40654933›Full record

ArticlebioRxiv : the preprint server for biology2025

m5C RNA Methylation Is Dysregulated by Oncogenic Herpesviruses via c-Myc Signaling to Counteract Host Antiviral Factors.

Zhenyu Wu, Dawei Zhou, Zhixian He, Guillaume N Fiches, Youngmin Park, Jinshan He, Jianwen Chen, Kateepe Arachchige Sudeera Nuwan Shanaka, Thurbu Tshering Lepcha, Prashant Desai and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Zhenyu WuDepartment of Pathology, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
Dawei ZhouDepartment of Pathology, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
Zhixian HeDepartment of Microbiology, College of Arts and Sciences, The Ohio State University, Columbus, OH 43210, USA.
Guillaume N FichesDepartment of Pathology, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
Youngmin ParkDepartment of Pathology, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
Jinshan HeDepartment of Pathology, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
Jianwen ChenDepartment of Pathology, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
Kateepe Arachchige Sudeera Nuwan ShanakaDepartment of Pathology, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
Thurbu Tshering LepchaDepartment of Pathology, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
Prashant DesaiDepartment of Oncology, School of Medicine, The Johns Hopkins University, Baltimore, MD 21224, USA.
Jian ZhuDepartment of Pathology, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
Netty G SantosoDepartment of Pathology, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.

Funding

Investigate Host Gene Isoforms Contributing to HIV Persistence in Cocaine UsersR01DA059538 · NIDA · OHIO STATE UNIVERSITY · PI Wei Jiang, Jian Zhu · 2023 to 2026
$2.9M
Target Host Epigenetic Regulation of HIV Proviruses to Reinforce Viral Deep Latency in MicrogliaR01MH134402 · NIMH · OHIO STATE UNIVERSITY · PI HO, WENZHE, ZHU, JIAN · 2023 to 2025
$2.2M
(PQ4) Role of HIV-induced PLK1 Activation in Regulation of gamma-Herpesvirus Reservoirs in LymphocytesR01CA260690 · NCI · OHIO STATE UNIVERSITY · PI SANTOSO, NETTY G · 2021 to 2025
$1.9M
Antagonize Host Survival and Immune Escape Mechanisms for Elimination of HIV Viral ReservoirsR56AI181631 · NIAID · OHIO STATE UNIVERSITY · PI LING, BINHUA "JULIE", ZHU, JIAN · 2024 to 2024
$842k
Role of RNA Methylation in Regulating HIV Proviral ExpressionR56AI157872 · NIAID · OHIO STATE UNIVERSITY · PI ZHU, JIAN · 2021 to 2021
$374k
Inhibition of TIP60 by Latent Gammaherpesviruses in B-cell LymphomasR03DE029716 · NIDCR · OHIO STATE UNIVERSITY · PI SANTOSO, NETTY G · 2020 to 2021
$312k
NCI NIH HHS R01 CA260690NIAID NIH HHS R56 AI157872NIAID NIH HHS R56 AI181631NIDA NIH HHS R01 DA059538NIDCR NIH HHS R03 DE029716NIMH NIH HHS R01 MH134402
6 · The paper itself

Abstract

Herpesviruses are a group of double-stranded DNA viruses known to develop versatile viral strategies to escape host immune surveillance for promoting their replication and propagation. This is illustrated by Kaposi's sarcoma-associated herpesvirus (KSHV), an oncogenic gamma-herpesvirus that overcomes host immune suppression by multiple mechanisms. In this study, we reported that KSHV dysregulates 5-methylcytosine (m5C) modification and mRNA stability of host antiviral factors to benefit its lytic replication. KSHV lytic reactivation or

Indexed as

c-MycKSHVlatencylytic replicationNSUN1NSUN2reactivationRNA modificationTRIM25

Identifiers

PMID40654933
PMCPMC12248048

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.