ArticlebioRxiv : the preprint server for biology2025
Robust CENP-A incorporation in human cells is independent of transcription and cohesin components.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Centromeres are essential chromosomal components that ensure proper cell division by serving as assembly sites for kinetochores, which connect chromosomes to spindle microtubules. Centromeres are marked by the evolutionarily conserved centromere-specific histone H3 variant, CENP-A, which is deposited into centromere nucleosomes during G1 in human cells. Centromeres retain cohesin, a ring-like protein complex during mitosis, protecting sister chromatid cohesion and centromere transcription to prevent chromosome missegregation. Previous work in
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