Evidence map›Paper›PMID 40654904›Full record

ArticlebioRxiv : the preprint server for biology2025

Extracellular vesicles from a model of melanoma cancer-associated fibroblasts induce changes in brain microvascular cells consistent with pre-metastatic niche priming.

M Shelton, C A Anene, J Nsengimana, M K Eldahshoury, B Keane, W Roberts, J Newton-Bishop, J R Boyne

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

M SheltonCentre for Biomedical Science Research, School of Health, Leeds Beckett University, Leeds, UK.
C A AneneCentre for Biomedical Science Research, School of Health, Leeds Beckett University, Leeds, UK.ORCID 0000-0002-3591-3358
J NsengimanaPopulation Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle, NE2 4BN, UK.
M K EldahshouryCentre for Biomedical Science Research, School of Health, Leeds Beckett University, Leeds, UK.
B KeanePopulation Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle, NE2 4BN, UK.
W RobertsCentre for Biomedical Science Research, School of Health, Leeds Beckett University, Leeds, UK.
J Newton-BishopUniversity of Leeds School of Medicine, Leeds, United Kingdom, UK.
J R BoyneCentre for Biomedical Science Research, School of Health, Leeds Beckett University, Leeds, UK.ORCID 0000-0003-1219-6453

Funding

Genetic Epidermiology of MelanomaR01CA083115 · NCI · UNIVERSITY OF PENNSYLVANIA · PI BISHOP, DAVID TIMOTHY, ELDER, DAVID ERIC · 2001 to 2017
$13.0M
NCI NIH HHS R01 CA083115
6 · The paper itself

Abstract

Malignant melanoma has one of the lowest 5-year survival rates of any cancer, and is recognised for being particularly invasive and metastatic, with the poorest survival outcomes in brain metastases patients. A key characteristic of these tumours is crosstalk between melanoma cells and cells of the tumour microenvironment (TME), such as cancer associated fibroblasts (CAFs). The role of melanoma-derived small extracellular vesicles (sEVs) in potentiating CAFs has been studied extensively, however the role of CAF sEVs in regulation of the local TME and distal pre-metastatic niche (PMN) is less clear. Here, we demonstrate that sEVs derived from an

Indexed as

Cancer-associated fibroblastsextracellular vesiclesMelanoma brain metastasisPre-metastatic niche remodellingTumour microenvironment

Identifiers

PMID40654904
PMCPMC12247731

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.