Evidence map›Paper›PMID 40654891›Full record

ArticlebioRxiv : the preprint server for biology2025

Contributions of Folded and Disordered Domains to RNA Binding by HNRNPR.

Bryan B Guzmán, Grant A Goda, Alli Jimenez, Justin G Martyr, Yue Hu, Francisco F Cavazos, Maria M Aleman, Daniel Dominguez

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Bryan B GuzmánDepartment of Pharmacology, University of North Carolina, Chapel Hill, NC.ORCID 0000-0002-2711-9533
Grant A GodaDepartment of Pharmacology, University of North Carolina, Chapel Hill, NC.ORCID 0000-0002-7325-2490
Alli JimenezDepartment of Pharmacology, University of North Carolina, Chapel Hill, NC.ORCID 0009-0002-5251-9990
Justin G MartyrDepartment of Pharmacology, University of North Carolina, Chapel Hill, NC.ORCID 0000-0002-0057-5387
Yue HuDepartment of Pharmacology, University of North Carolina, Chapel Hill, NC.ORCID 0000-0002-2858-0831
Francisco F CavazosDepartment of Pharmacology, University of North Carolina, Chapel Hill, NC.
Maria M AlemanDepartment of Pharmacology, University of North Carolina, Chapel Hill, NC.ORCID 0000-0002-1714-0363
Daniel DominguezDepartment of Pharmacology, University of North Carolina, Chapel Hill, NC.

Funding

Pre-doctoral Training Program in Integrative Vascular BiologyT32HL069768 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Christopher P. Mack · 2002 to 2026
$9.7M
Research Training in Hematology at UNC Chapel HillT32HL007149 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Nigel S. Key · 1985 to 2026
$8.6M
Predoctoral Training in the Pharmacological SciencesT32GM135095 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Joseph Mauro Calabrese, Michael James Emanuele · 2020 to 2026
$3.6M
Protein Disorder as a Modifier of RNA Binding and RegulationR35GM142864 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Daniel Issac Dominguez · 2021 to 2026
$2.5M
Molecular and Cellular Biophysics Training GrantT32GM148376 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Matthew R Redinbo, Qi Zhang · 2024 to 2026
$1.4M
NHLBI NIH HHS T32 HL007149NHLBI NIH HHS T32 HL069768NIGMS NIH HHS R35 GM142864NIGMS NIH HHS T32 GM135095NIGMS NIH HHS T32 GM148376
6 · The paper itself

Abstract

RNA binding proteins (RBPs) interact with and tightly regulate the fate of messenger RNAs but how RNA targets are recognized remains a challenging question. RBPs often contain multiple domains known to directly bind RNA, such as RNA recognition motifs (RRMs), as well as domains whose RNA binding capacity remains incompletely understood,

Identifiers

PMID40654891
PMCPMC12247724

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.