Evidence map›Paper›PMID 40654859›Full record

ArticlebioRxiv : the preprint server for biology2025

Promoter strength and position govern promoter competition.

Mervenaz Koska, Tomek Swigut, Alistair Nicol Boettiger, Joanna Wysocka

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Mervenaz KoskaDepartment of Chemical and Systems Biology, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0003-3341-2979
Tomek SwigutDepartment of Chemical and Systems Biology, Stanford University, Stanford, CA 94305, USA.
Alistair Nicol BoettigerDepartment of Developmental Biology, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-3554-5196
Joanna WysockaDepartment of Chemical and Systems Biology, Stanford University, Stanford, CA 94305, USA.

Funding

Uncovering fundamentals of gene regulation by enhancersR35GM131757 · NIGMS · STANFORD UNIVERSITY · PI Joanna Wysocka · 2019 to 2026
$3.1M
NIGMS NIH HHS R35 GM131757
6 · The paper itself

Abstract

Competition between promoters within a shared regulatory landscape has been implicated in development and disease, but the determinants of promoter competition have not been systematically studied. Here, we use a synthetic platform to introduce diverse promoters at defined genomic sites within the

Identifiers

PMID40654859
PMCPMC12247958

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.