Evidence map›Paper›PMID 40654857›Full record

ArticlebioRxiv : the preprint server for biology2025

Soma to neuron communication links stress adaptation to stress avoidance behavior.

Julia Witrado, Ella Gundrum, Maria Victoria Veroli, A J Gilsrud, Mahdi Eskandarisani, Ioannis K Zervantonakis, Steven Mullett, Stacy Gelhaus, Todd Lamitina

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Julia WitradoDivision of Child Neurology, Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Ella GundrumDivision of Child Neurology, Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Maria Victoria VeroliDivision of Child Neurology, Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
A J GilsrudCenter for Neuroscience at the University of Pittsburgh Graduate Training Program.
Mahdi EskandarisaniDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.
Ioannis K ZervantonakisDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.
Steven MullettDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261.
Stacy GelhausDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261.
Todd LamitinaDivision of Child Neurology, Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.ORCID 0000-0001-7332-9075

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Regulation of stress-specific protein translation by the O-GlcNaC transferase ogt-1 and 3' mRNA processingR01GM135577 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LAMITINA, SAMUEL T · 2020 to 2023
$1.5M
Bringing Untargeted Metabolomics to PittS10OD023402 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GELHAUS, STACY LYNN · 2018 to 2018
$594k
NIGMS NIH HHS R01 GM135577NIH HHS P40 OD010440NIH HHS S10 OD023402
6 · The paper itself

Abstract

In multicellular organisms, signaling from the nervous system to the peripheral tissues can activate physiological responses to stress. Here, we show that inter-tissue stress communication can also function in reverse, i.e. from the peripheral tissue to the nervous system.

Identifiers

PMID40654857
PMCPMC12248090

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.