Evidence map›Paper›PMID 40654835›Full record

ArticlebioRxiv : the preprint server for biology2025

GUIDING CLUSTERING AND ANNOTATION IN SINGLE-CELL RNA SEQUENCING USING THE AVERAGE OVERLAP METRIC.

Christopher Thai, Amartya Singh, Daniel Herranz, Hossein Khiabanian

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Christopher ThaiRutgers Cancer Institute, Rutgers University, New Brunswick, NJ 08901, USA.
Amartya SinghRutgers Cancer Institute, Rutgers University, New Brunswick, NJ 08901, USA.
Daniel HerranzRutgers Cancer Institute, Rutgers University, New Brunswick, NJ 08901, USA.ORCID 0000-0003-1768-5969
Hossein KhiabanianRutgers Cancer Institute, Rutgers University, New Brunswick, NJ 08901, USA.ORCID 0000-0003-1446-4394

Funding

Rutgers Biotechnology Training ProgramT32GM135141 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI ANN M. STOCK, Martin L Yarmush · 2020 to 2026
$3.5M
The role of glutaminolysis as a therapeutic target in T-ALLR01CA236936 · NCI · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI HERRANZ, DANIEL · 2019 to 2023
$1.8M
The role of pyruvate kinase as a therapeutic target in T-ALLR01CA285513 · NCI · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI Daniel Herranz · 2024 to 2026
$1.1M
NCI NIH HHS R01 CA236936NCI NIH HHS R01 CA285513NIGMS NIH HHS T32 GM135141
6 · The paper itself

Abstract

Defining cell types using unsupervised clustering algorithms based on transcriptional similarity is a powerful application of single-cell RNA sequencing. A single clustering resolution may not yield clusters that represent both broad, well-defined populations and smaller subpopulations simultaneously. Therefore, when cell identities are not known prior to sequencing, robust comparison and annotation of inferred

Identifiers

PMID40654835
PMCPMC12247988

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.